webPRC: the Profile Comparer for alignment-based searching of public domain databases.
webPRC: the Profile Comparer for alignment-based searching of public domain databases.
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DOI：
10.1093/nar/gkp279
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发表时间：
2009-07
影响因子：
14.9
通讯作者：
Heringa J
中科院分区：
文献类型：
--
作者：
Brandt BW;Heringa J
概况 - 培训方法非常适合检测蛋白质家族之间的远程进化关系轮廓HMM而不是序列，可用于查找遥远的同源物PRC是一个配置文件比较，它仅报告hmm对齐，并且没有产生多个序列对齐，我们已经开发了WebPRC服务器，这使得在许多域数据库中搜索遥远的同源物或类似的比对。结果既是多个序列比对，又是对齐的HMM。编辑器并从对齐的HMM或对齐的多个对齐。 .nl/program/prcwww/。
Profile–profile methods are well suited to detect remote evolutionary relationships between protein families. Profile Comparer (PRC) is an existing stand-alone program for scoring and aligning hidden Markov models (HMMs), which are based on multiple sequence alignments. Since PRC compares profile HMMs instead of sequences, it can be used to find distant homologues. For this purpose, PRC is used by, for example, the CATH and Pfam-domain databases. As PRC is a profile comparer, it only reports profile HMM alignments and does not produce multiple sequence alignments. We have developed webPRC server, which makes it straightforward to search for distant homologues or similar alignments in a number of domain databases. In addition, it provides the results both as multiple sequence alignments and aligned HMMs. Furthermore, the user can view the domain annotation, evaluate the PRC hits with the Jalview multiple alignment editor and generate logos from the aligned HMMs or the aligned multiple alignments. Thus, this server assists in detecting distant homologues with PRC as well as in evaluating and using the results. The webPRC interface is available at http://www.ibi.vu.nl/programs/prcwww/.
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Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
通讯作者：
Bateman, Alex
影响因子：
5.8
作者：
Bateman, Alex;Finn, Robert D.
通讯作者：
Finn, Robert D.
影响因子：
14.9
作者：
Sadreyev RI;Grishin NV
通讯作者：
Grishin NV
影响因子：
3
作者：
Schuster-Böckler, B;Schultz, J;Rahmann, S
通讯作者：
Rahmann, S
影响因子：
5.8
作者：
Vacic, Vladimir;Iakoucheva, Lilia M.;Radivojac, Predrag
通讯作者：
Radivojac, Predrag