Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.
Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction.
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DOI：
10.1111/j.1749-6632.2009.05143.x
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发表时间：
2010-02
影响因子：
5.2
通讯作者：
Renshaw PF
中科院分区：
文献类型：
--
作者：
Licata SC;Renshaw PF
质子磁共振波谱（1H MRS）是一种非侵入性成像技术，可以测量感兴趣组织内的特定化合物或代谢物。在大脑中，1H MRS提供了定义的感兴趣体积内的神经化学环境的快照。文献检索表明，这种技术在表征肿瘤、跟踪神经退行性疾病的进展以及了解精神疾病的神经生物学基础方面具有广泛的实用性。相对最近，1H MRS已经进入药物滥用研究，并且开始被认为是脑成像工具箱中的有价值的补充，该工具箱还包含正电子发射断层扫描（PET），单光子发射计算机断层扫描（SPECT）和功能性磁共振成像（fMRI）。使用1H MRS的药物滥用研究已经确定了大脑中的一些生化变化。药物类别中最一致的变化是N-乙酰天冬氨酸减少和肌醇升高，而胆碱、肌酸和氨基酸递质的变化也很丰富。总之，本文讨论的研究提供了证据，表明滥用药物可能对神经元健康、能量代谢和维持、炎症过程、细胞膜更新和神经传递产生深远影响，这些生化变化可能是脑组织内神经病理学的基础，随后引起与药物成瘾相关的认知和行为障碍。
Proton magnetic resonance spectroscopy (1H MRS) is a non-invasive imaging technique that permits measurement of particular compounds or metabolites within the tissue of interest. In the brain, 1H MRS provides a snapshot of the neurochemical environment within a defined volume of interest. A search of the literature demonstrates the widespread utility of this technique for characterizing tumors, tracking the progress of neurodegenerative disease, and for understanding the neurobiological basis of psychiatric disorders. As of relatively recently, 1H MRS has found its way into substance abuse research, and it is beginning to become recognized as a valuable complement in the brain imaging toolbox that also contains positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). Drug abuse studies employing 1H MRS have identified a number biochemical changes in the brain. The most consistent alterations across drug class were reductions in N-acetylaspartate and elevations in myo-inositol, while changes in choline, creatine, and amino acid transmitters also were abundant. Together, the studies discussed herein provide evidence that drugs of abuse may have a profound impact on neuronal health, energy metabolism and maintenance, inflammatory processes, cell membrane turnover, and neurotransmission, and these biochemical changes may underlie the neuropathology within brain tissue that subsequently gives rise to the cognitive and behavioral impairments associated with drug addiction.
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影响因子：
4.2
作者：
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通讯作者：
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