Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury.
Roadmap for Advancing Pre-Clinical Science in Traumatic Brain Injury.
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DOI：
10.1089/neu.2021.0094
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发表时间：
2021-12
影响因子：
4.2
通讯作者：
Crawford F
中科院分区：
文献类型：
--
作者：
Smith DH;Kochanek PM;Rosi S;Meyer R;Ferland-Beckham C;Prager EM;Ahlers ST;Crawford F
长期以来，疾病的临床前模型在新治疗方法的发展中发挥着重要作用。然而，在创伤性脑损伤（TBI），尽管有许多模型系统的可用性，从板凳到床边的翻译仍然难以捉摸。将临床相关性整合到临床前模型开发中是推进TBI患者治疗的关键一步。临床前模型包括体内和体外动物实验（包括小型和大型）以及体外建模。广泛的临床前模型反映了在人类中复制TBI后遗症的多个方面的大量尝试。虽然这些模型揭示了TBI病理生理学的多种假定机制，但未能将这些发现转化为成功的临床试验，这就对模型的临床相关性和适用性提出了质疑。在这里，我们解决了临床前模型的承诺和陷阱，其目标是发展框架，以推进跨模型，损伤类型和病理学异质性病因学的转化TBI研究。
Pre-clinical models of disease have long played important roles in the advancement of new treatments. However, in traumatic brain injury (TBI), despite the availability of numerous model systems, translation from bench to bedside remains elusive. Integrating clinical relevance into pre-clinical model development is a critical step toward advancing therapies for TBI patients across the spectrum of injury severity. Pre-clinical models include in vivo and ex vivo animal work—both small and large—and in vitro modeling. The wide range of pre-clinical models reflect substantial attempts to replicate multiple aspects of TBI sequelae in humans. Although these models reveal multiple putative mechanisms underlying TBI pathophysiology, failures to translate these findings into successful clinical trials call into question the clinical relevance and applicability of the models. Here, we address the promises and pitfalls of pre-clinical models with the goal of evolving frameworks that will advance translational TBI research across models, injury types, and the heterogenous etiology of pathology.
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影响因子：
5.6
作者：
Chou A;Krukowski K;Morganti JM;Riparip LK;Rosi S
通讯作者：
Rosi S
DOI：
10.3233/jad-180726
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
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通讯作者：
Xia W
影响因子：
3.7
作者：
Chou A;Morganti JM;Rosi S
通讯作者：
Rosi S
影响因子：
4.2
作者：
Bartnik-Olson, Brenda L.;Holshouser, Barbara;Ashwal, Stephen
通讯作者：
Ashwal, Stephen
影响因子：
4.2
作者：
Albalawi, Tamadher;Hamner, Jason W.;Tan, Can Ozan
通讯作者：
Tan, Can Ozan