Key transcription factors in the differentiation of mesenchymal stem cells.
Key transcription factors in the differentiation of mesenchymal stem cells.
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DOI：
10.1016/j.diff.2016.02.005
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发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Almalki SG;Agrawal DK
间充质干细胞（MSC）是多能细胞，代表再生医学的一个有前途的来源。MSC能够成骨分化、成软骨分化、成脂分化和成肌分化。分化的MSC在损伤组织中再生细胞的功效需要维持朝向所需细胞命运的分化的能力。由于骨髓间充质干细胞是一个有吸引力的来源，自体移植，细胞和分子的信号转导途径和微环境的变化进行了研究，以了解细胞因子，趋化因子和转录因子的骨髓间充质干细胞的分化的作用。MSC分化为间充质谱系是由与特定细胞谱系相关的特异性转录因子遗传操纵和促进的。最近的研究探索了转录因子Runx2、Sox 9、PPARγ、MyoD、GATA 4和GATA 6在MSC分化中的整合。因此，单个转录因子在MSC中的过表达可能促进向特定细胞谱系的转分化，这可用于治疗某些疾病。在这篇综述中，我们批判性地讨论和评估的作用，影响骨髓间充质干细胞向脂肪细胞，软骨细胞，骨细胞，骨骼肌细胞，心肌细胞和平滑肌细胞的分化的转录因子和相关的信号通路。
Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and myogenic differentiation. Efficacy of differentiated MSCs to regenerate cells in the injured tissues requires the ability to maintain the differentiation toward the desired cell fate. Since MSCs represent an attractive source for autologous transplantation, cellular and molecular signaling pathways and micro-environmental changes have been studied in order to understand the role of cytokines, chemokines, and transcription factors on the differentiation of MSCs. The differentiation of MSC into a mesenchymal lineage is genetically manipulated and promoted by specific transcription factors associated with a particular cell lineage. Recent studies have explored the integration of transcription factors, including Runx2, Sox9, PPARγ, MyoD, GATA4, and GATA6 in the differentiation of MSCs. Therefore, the overexpression of a single transcription factor in MSCs may promote trans-differentiation into specific cell lineage, which can be used for treatment of some diseases. In this review, we critically discussed and evaluated the role of transcription factors and related signaling pathways that affect the differentiation of MSCs toward adipocytes, chondrocytes, osteocytes, skeletal muscle cells, cardiomyocytes, and smooth muscle cells.
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影响因子：
3.4
作者：
Charytonowicz, Elizabeth;Matushansky, Igor;Ziman, Mel
通讯作者：
Ziman, Mel
影响因子：
11.4
作者：
Braun, T;Arnold, HH
通讯作者：
Arnold, HH
影响因子：
3.7
作者：
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通讯作者：
Bruni P
DOI：
10.1111/j.1365-2184.1987.tb01309.x
发表时间：
1987-05-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
FRIEDENSTEIN, AJ;CHAILAKHYAN, RK;GERASIMOV, UV
通讯作者：
GERASIMOV, UV
影响因子：
3.3
作者：
Fujii, M;Takeda, K;Miyazono, K
通讯作者：
Miyazono, K