Suppressible four-base glycine and proline codons in yeast.

Suppressible four-base glycine and proline codons in yeast.
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酵母中可抑制的四碱基甘​​氨酸和脯氨酸密码子。

DOI:
10.1126/science.7010605
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发表时间:
1981
期刊:
影响因子:
56.9
通讯作者:
G. Fink
G. Fink
中科院分区:
综合性期刊1区
文献类型:
--
作者:
T. Donahue;P. Farabaugh;G. Fink

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ICR-170诱导的酵母His 4基因座的五个突变是在含有多个G. C碱基对的DNA区域中添加+1 G. C(G,鸟嘌呤; C,胞嘧啶)。这些突变代表不可抑制和可抑制的等位基因。在所有外部,甘氨酸和脯氨酸密码子中发生可抑制的移码突变,以产生四碱基密码子GGGU(U,尿嘧啶)、GGGG和CCCU。这意味着在酵母中抑制这些四碱基密码子,就像在细菌中一样,涉及四碱基反密码子或其功能等同物。两个相同的四碱基密码子(CCCU)在广泛分开的区域与His 4没有被同等抑制。
Five ICR-170--induced mutations at the His4 locus in yeast are +1 G.C (G, guanine; C, cytosine) additions in DNA regions that contain multiple G.C base pairs. These mutations represents both nonsuppressible and suppressible alleles. All externally, suppressible frameshift mutations occur in glycine and proline codons to produce the four-base codons GGGU (U, uracil), GGGG, and CCCU. This implies that suppression of these four-base codons in yeast, as in bacteria, involves a four-base anticodon or its functional equivalent. Two identical four-base codons (CCCU) at widely separate regions with His4 are not suppressed equally.
DOI: 10.1093/genetics/95.4.855
发表时间: 1980
期刊: Genetics
影响因子: 3.3
作者:
Cummins,CM;Gaber,RF;Culbertson,MR;Mann,R;Fink,GR
通讯作者: Fink,GR
DOI: 10.1093/genetics/95.4.833
发表时间: 1980
期刊: Genetics
影响因子: 3.3
作者:
Culbertson,MR;Underbrink,KM;Fink,GR
通讯作者: Fink,GR