Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.
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DOI：
10.1038/s41467-021-21245-w
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发表时间：
2021-02-10
影响因子：
16.6
通讯作者：
Schaeffer EM
中科院分区：
文献类型：
--
作者：
Weiner AB;Vidotto T;Liu Y;Mendes AA;Salles DC;Faisal FA;Murali S;McFarlane M;Imada EL;Zhao X;Li Z;Davicioni E;Marchionni L;Chinnaiyan AM;Freedland SJ;Spratt DE;Wu JD;Lotan TL;Schaeffer EM
黑人男性更常死于前列腺癌，但有趣的是，sipuleucel-T的免疫治疗可能会带来更大的生存益处。由于前列腺癌不存在免疫应答的特征，我们探索了基于种族的免疫谱来识别漏洞。在这里，我们显示在由超过1，300个患者样本组成的多个独立队列中，这些患者样本注释有自我识别的种族或遗传血统，来自黑人男性或非洲血统男性的前列腺肿瘤的浆细胞浸润增加，NK细胞活性和IgG表达的标志物增加。这些发现与手术后无复发生存率的提高有关，并将浆细胞作为前列腺癌免疫反应的驱动因素。最近的一份报告表明，患有前列腺癌的黑人男性对免疫疗法更敏感。在这里，作者分析了前列腺癌基因表达谱，并显示与白色男性相比，黑人男性和非洲血统男性的肿瘤浆细胞比例增加，这与治疗后改善的结果相关。
Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness. A recent report suggested Black men with prostate cancer were more responsive to immunotherapy. Here, the authors analysed prostate cancer gene expression profiles and show tumours from Black men and men with African ancestry have an increased proportion of plasma cells compared to those of White men and this correlates with improved outcome following treatment.
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影响因子：
4.6
作者：
Bankhead P;Loughrey MB;Fernández JA;Dombrowski Y;McArt DG;Dunne PD;McQuaid S;Gray RT;Murray LJ;Coleman HG;James JA;Salto-Tellez M;Hamilton PW
通讯作者：
Hamilton PW
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
64.8
作者：
Helmink BA;Reddy SM;Gao J;Zhang S;Basar R;Thakur R;Yizhak K;Sade-Feldman M;Blando J;Han G;Gopalakrishnan V;Xi Y;Zhao H;Amaria RN;Tawbi HA;Cogdill AP;Liu W;LeBleu VS;Kugeratski FG;Patel S;Davies MA;Hwu P;Lee JE;Gershenwald JE;Lucci A;Arora R;Woodman S;Keung EZ;Gaudreau PO;Reuben A;Spencer CN;Burton EM;Haydu LE;Lazar AJ;Zapassodi R;Hudgens CW;Ledesma DA;Ong S;Bailey M;Warren S;Rao D;Krijgsman O;Rozeman EA;Peeper D;Blank CU;Schumacher TN;Butterfield LH;Zelazowska MA;McBride KM;Kalluri R;Allison J;Petitprez F;Fridman WH;Sautès-Fridman C;Hacohen N;Rezvani K;Sharma P;Tetzlaff MT;Wang L;Wargo JA
通讯作者：
Wargo JA
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
影响因子：
64.8
作者：
Cabrita, Rita;Lauss, Martin;Jonsson, Goran
通讯作者：
Jonsson, Goran