A quasi-nonlinear analysis of the anisotropic behaviour of human gallbladder wall.

A quasi-nonlinear analysis of the anisotropic behaviour of human gallbladder wall.
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人胆囊壁各向异性行为的准非线性分析。

DOI:
10.1115/1.4007633
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发表时间:
2012
期刊:
Journal of biomechanical engineering
影响因子:
--
通讯作者:
Li WG
Li WG
中科院分区:
--
文献类型:
--
作者:
Li WG

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软组织生物力学参数的非侵入性测量估计具有临床意义,在病人的具体建模和疾病诊断。在这项工作中,我们提出了一个准非线性的方法,用于估计人体胆囊壁的弹性模量。采用基于横观各向同性膜材料模型的正演方法,通过逆迭代确定胆囊两幅连续超声图像之间的周向和纵向弹性模量。结果表明,人体胆囊的行为在各向异性的方式,本构模型需要将此。估计的模量也是非线性的和患者相关的。重要的是,这里预测的峰值应力不同于线性膜理论的早期估计。由于已经发现胆囊壁内的峰值应力与非结石性胆囊疼痛密切相关,因此如果将该信息用于临床诊断,则胆囊组织的可靠机械建模至关重要。
Estimation of biomechanical parameters of soft tissues from noninvasive measurements has clinical significance in patient-specific modeling and disease diagnosis. In this work, we present a quasi-nonlinear method that is used to estimate the elastic moduli of the human gallbladder wall. A forward approach based on a transversely isotropic membrane material model is used, and an inverse iteration is carried out to determine the elastic moduli in the circumferential and longitudinal directions between two successive ultrasound images of gallbladder. The results demonstrate that the human gallbladder behaves in an anisotropic manner, and constitutive models need to incorporate this. The estimated moduli are also nonlinear and patient dependent. Importantly, the peak stress predicted here differs from the earlier estimate from linear membrane theory. As the peak stress inside the gallbladder wall has been found to strongly correlate with acalculous gallbladder pain, reliable mechanical modeling for gallbladder tissue is crucial if this information is to be used in clinical diagnosis.
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