T-cell Posttransplant Lymphoproliferative Disorder Occurring in a Pediatric Solid-organ Transplant Patient
T-cell Posttransplant Lymphoproliferative Disorder Occurring in a Pediatric Solid-organ Transplant Patient
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儿科实体器官移植患者发生 T 细胞移植后淋巴增殖性疾病
DOI：
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发表时间：
2004
影响因子：
5.6
通讯作者：
M. Lim
中科院分区：
文献类型：
--
作者：
R. Lundell;K. Elenitoba;M. Lim
移植后淋巴增殖性疾病（PTLD）是移植患者因免疫抑制剂治疗而出现的严重并发症。大多数病例是 B 细胞来源的，通常与 Epstein-Barr 病毒 (EBV) 感染有关。 T 细胞 PTLD 很少见，之前仅报道了 13 例具有临床病理相关性的儿童 T 细胞 PTLD。我们介绍了一名儿科患者在原位肝移植后发现的单形性 PTLD（T 细胞淋巴瘤）的组织学、免疫表型和分子特征。在回肠、直肠和肠系膜淋巴结中发现了淋巴瘤。原位杂交显示大量 EBER-1 阳性肿瘤细胞。还讨论了当前的文献综述。在文献报道的 14 例儿童 T 细胞 PTLD 病例中，只有 3 例（21.4%）被描述为 EBV 阳性。大多数报道的 PTLD 都是单克隆的，11 例中有 9 例 (82%) 通过基因重排研究显示出克隆性 T 细胞群。 T 细胞 PTLD 病例似乎预后较差（14 名患者中有 11 名死于该病），尽管涉及特定解剖部位的患者可能有更好的结果。
Posttransplantation lymphoproliferative disorder (PTLD) is a serious complication seen in transplant patients as a consequence of immunosuppressant therapy. Most cases are of B-cell origin and are commonly associated with Epstein-Barr virus (EBV) infection. T-cell PTLDs are rare and only 13 pediatric T-cell PTLDs with clinicopathologic correlation have been reported previously. We present the histologic, immunophenotypic, and molecular features of a monomorphic PTLD (T-cell lymphoma) identified in a pediatric patient following orthotopic liver transplantation. The lymphoma was identified in the ileum, rectum, and mesenteric lymph nodes. In situ hybridization revealed numerous EBER-1-positive tumor cells. A current review of the literature is also discussed. Of the 14 cases of pediatric T-cell PTLD reported in the literature, only 3 (21.4%) are described as being EBV positive. Most of the reported PTLDs are monoclonal, with 9 of 11 cases (82%) showing a clonal T-cell population by gene rearrangement studies. T-cell PTLD cases appear to have a poor prognosis (11 of 14 patients died of the disease), although patients with involvement of specific anatomic sites may have a better outcome.
心脏移植受者淋巴增殖性病变的单克隆性。
DOI：
10.1056/nejm198402233100801
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cleary,ML;Warnke,R;Sklar,J
通讯作者：
Sklar,J
影响因子：
20.3
作者：
E. Waller;M. Ziemiańska;C. Bangs;Michael L. Cleary;I. Weissman;O. Kamel
通讯作者：
E. Waller;M. Ziemiańska;C. Bangs;Michael L. Cleary;I. Weissman;O. Kamel