Linear atrial ablations in a canine model of chronic atrial fibrillation: morphological and electrophysiological observations.
Linear atrial ablations in a canine model of chronic atrial fibrillation: morphological and electrophysiological observations.
复制标题
慢性心房颤动犬模型中的线性心房消融：形态学和电生理学观察。
DOI：
10.1161/01.cir.97.12.1176
复制
发表时间：
1998
期刊：
影响因子：
37.8
通讯作者：
D. Haines
中科院分区：
文献类型：
--
作者：
M. Mitchell;I. McRury;D. Haines
背景
为了验证线性心房消融可能降低持续性房颤易感性的假设，我们建立了慢性房颤犬模型，并使用新型导管设计来创建心房消融。
方法和结果
在16只狗中，通过制造二尖瓣返流和快速心房起搏来诱发慢性心房颤动。在11只犬（消融组）中沿经验推导的预选心房靶部位尝试沿着进行温控射频消融，并在5只犬（对照组）中进行假手术。术后13+/-5天进行随访电生理学检查和病理学检查。消融术后，9只存活消融犬中有1只和5只对照犬中有5只可立即启动持续性房颤（P=.004）。4只犬在手术后24小时内死亡。4只犬需要永久起搏。随访时，7只消融犬中0只和5只对照犬中5只发生房颤（P=.001）。此外，7只消融犬中有2只出现持续性房性心动过速，其中1只成功消融。病理学检查显示经常出现不完整的病灶集和不连续的病灶。
结论
在该模型中，通过使用专门设计的线圈电极导管进行长线性心房消融，可以降低持续性房颤的易感性。达到治疗效果不需要完全的病变连续性。
BACKGROUND
To test the hypothesis that susceptibility to sustained atrial fibrillation may be decreased by creation of linear atrial ablations, we established a canine model of chronic atrial fibrillation and used a novel catheter design to create atrial ablations.
METHODS AND RESULTS
Chronic atrial fibrillation was induced in 16 dogs by creation of mitral regurgitation and rapid pacing of the atria. Temperature-controlled radiofrequency ablations were attempted along empirically derived, preselected atrial target sites in 11 dogs (ablation group), and a sham procedure was performed in 5 dogs (control group). Follow-up electrophysiology study and pathological examination were conducted 13+/-5 days after the initial procedure. Immediately after ablation, sustained atrial fibrillation could be initiated in 1 of 9 surviving ablation dogs and 5 of 5 controls (P=.004). Four dogs died within 24 hours of the procedure. Permanent pacing was required in 4 dogs. At follow-up, 0 of 7 ablation dogs and 5 of 5 controls had atrial fibrillation (P=.001). Furthermore, 2 of 7 ablation dogs had sustained atrial tachycardias, one of which was successfully ablated. Pathological examination demonstrated frequent incomplete lesion sets and discontinuous lesions.
CONCLUSIONS
In this model, a reduction in the susceptibility to sustained atrial fibrillation can be achieved by long linear atrial ablations created with specially designed coil electrode catheters. Complete lesion continuity was not required to achieve a therapeutic effect.
DOI：
10.1016/s0022-5223(19)36684-x
发表时间：
1991-04-01
影响因子：
6
作者：
COX, JL;SCHUESSLER, RB;BOINEAU, JP
通讯作者：
BOINEAU, JP
影响因子：
4.6
作者：
COX, JL;BOINEAU, JP;CRAWFORD, FA
通讯作者：
CRAWFORD, FA