Macrophages-Key cells in the response to wear debris from joint replacements.
Macrophages-Key cells in the response to wear debris from joint replacements.
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DOI：
10.1002/jbm.a.34599
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发表时间：
2013-10
影响因子：
4.9
通讯作者：
Gallo, Jiri
中科院分区：
文献类型：
--
作者：
Nich, Christophe;Takakubo, Yuya;Pajarinen, Jukka;Ainola, Mari;Salem, Abdelhakim;Sillat, Tarvo;Rao, Allison J.;Raska, Milan;Tamaki, Yasunobu;Takagi, Michiaki;Konttinen, Yrjo T.;Goodman, Stuart B.;Gallo, Jiri
关键词：
磨损杂物的产生是关节置换物正常使用的必然结果。磨损碎片颗粒刺激局部和全身生物反应，导致慢性炎症，假体周围骨破坏，最终导致种植体松动和翻修手术。后者可能在使用常规聚乙烯关节置换术后的十年中适用于高达15%的患者。巨噬细胞在炎症和维持组织稳态中发挥多种作用。作为先天免疫系统的哨兵，它们是炎症级联启动的核心，其特征是释放促炎和促破骨因子。与对病原体的反应类似，磨损颗粒引起巨噬细胞的反应，基于属于这一谱系的细胞的独特特性，包括传感、趋化、吞噬和适应性刺激。所涉及的生物过程是复杂的，冗余的，既有局部的，也有系统的，并且具有高度的适应性。单核/巨噬细胞谱系的细胞参与了这一现象，最终导致骨吸收破骨细胞的分化和激活。同时，其他不同的巨噬细胞群抑制炎症并保护骨-植入物界面免受骨溶解。本文就单核/巨噬细胞谱系细胞的生理学现状进行综述。此外，还介绍了它们与磨损碎屑相互作用的模式和后果以及该领域的最新发展。
The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening and revision surgery. The latter may be indicated in up to 15% patients in the decade following the arthroplasty using conventional polyethylene. Macrophages play multiple roles in both inflammation and in maintaining tissue homeostasis. As sentinels of the innate immune system, they are central to the initiation of this inflammatory cascade, characterized by the release of pro-inflammatory and pro-osteoclastic factors. Similar to the response to pathogens, wear particles elicit a macrophage response, based on the unique properties of the cells belonging to this lineage, including sensing, chemotaxis, phagocytosis, and adaptive stimulation. The biological processes involved are complex, redundant, both local and systemic, and highly adaptive. Cells of the monocyte/macrophage lineage are implicated in this phenomenon, ultimately resulting in differentiation and activation of bone resorbing osteoclasts. Simultaneously, other distinct macrophage populations inhibit inflammation and protect the bone-implant interface from osteolysis. Here, the current knowledge about the physiology of monocyte/macrophage lineage cells is reviewed. In addition, the pattern and consequences of their interaction with wear debris and the recent developments in this field are presented.
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影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
4.2
作者：
Campbell, Pat;Ebramzadeh, Edward;Nelson, Scott;Takamura, Karren;De Smet, Koen;Amstutz, Harlan C.
通讯作者：
Amstutz, Harlan C.
影响因子：
32.4
作者：
Cros J;Cagnard N;Woollard K;Patey N;Zhang SY;Senechal B;Puel A;Biswas SK;Moshous D;Picard C;Jais JP;D'Cruz D;Casanova JL;Trouillet C;Geissmann F
通讯作者：
Geissmann F
DOI：
10.1097/01.blo.0000136839.90734.b7
发表时间：
2004-10-01
影响因子：
4.2
作者：
Clarke, MT;Roberts, CP;Rushton, N
通讯作者：
Rushton, N
影响因子：
4.8
作者：
Christensen, Brian;Klaning, Eva;Sorensen, Esben S.
通讯作者：
Sorensen, Esben S.