TAZ is highly expressed in gastric signet ring cell carcinoma.
TAZ is highly expressed in gastric signet ring cell carcinoma.
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TAZ 在胃印戒细胞癌中高表达
DOI：
10.1155/2014/393064
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发表时间：
2014
影响因子：
--
通讯作者：
Wei J
中科院分区：
文献类型：
--
作者：
Yue G;Sun X;Gimenez-Capitan A;Shen J;Yu L;Teixido C;Guan W;Rosell R;Liu B;Wei J
具有PDZ结合基序的转录辅激活因子（TAZ）与多种转录因子结合，控制细胞分化和器官发育。我们使用免疫组化（IHC）检测了146例II-IV期胃癌中的TAZ蛋白水平，同时在84例具有足够组织的样本中通过定量逆转录聚合酶链反应（QRT-PCR）确认了TAZ mRNA。146例胃癌组织中TAZ蛋白阳性表达113例（77.4%）。同时，在84例样本中的81例（96.4%）中成功检测到TAZ mRNA表达。TAZ蛋白表达与mRNA表达呈正相关（P = 0.018）。TAZ蛋白在印戒细胞癌（SRCC）组织学类型的胃癌组织中的阳性表达率明显高于腺癌（85.7%vs60.2%，P = 0.001）。TAZ mRNA在SRCC中的表达高于腺癌（P = 0.003）。与生存期相关时，所有患者的中位总生存期（OS）为14个月（95% CI：12.2-15.8个月）。生存率与其他临床特征或TAZ表达水平之间无显著相关性。我们的研究结果表明，TAZ在SRCC中高表达。TAZ有可能成为今后胃SRCC治疗的靶点。
Transcriptional coactivator with PDZ-binding motif (TAZ) is known to bind to a variety of transcription factors to control cell differentiation and organ development. We examined TAZ protein levels in 146 stage II–IV gastric cancer using immunohistochemistry (IHC), while TAZ mRNA was confirmed by quantitative reverse-transcription polymerase chain reaction (QRT-PCR) in 84 samples with enough tissue. TAZ protein expression was positive in 113 out of 146 (77.4%) gastric cancer samples. In parallel, TAZ mRNA expression was successfully detected in 81 of the 84 (96.4%) samples. Protein levels of TAZ were positively correlated with its mRNA levels (P = 0.018). High expression of TAZ protein was observed with higher percentage in gastric cancer samples with histology of signet ring cell carcinoma (SRCC) than adenocarcinoma (85.7% versus 60.2%, P = 0.001). Similarly, TAZ mRNA level was higher in SRCC than in adenocarcinoma (P = 0.003). When correlated with survival, the median overall survival (OS) is 14 months (95% CI: 12.2–15.8 months) in all patients. There was no significant association between survival and other clinical characteristics or TAZ expression levels. Our results show that TAZ is highly expressed in SRCC. TAZ might be considered as a target for the treatment of gastric SRCC in future.
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影响因子：
8.8
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影响因子：
3.7
作者：
Yuen HF;McCrudden CM;Huang YH;Tham JM;Zhang X;Zeng Q;Zhang SD;Hong W
通讯作者：
Hong W
影响因子：
45.3
作者：
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通讯作者：
Willis, Alliric I.
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影响因子：
5.3
作者：
Lei, Qun-Ying;Zhang, Heng;Guan, Kun-Liang
通讯作者：
Guan, Kun-Liang
影响因子：
11.4
作者：
Kanai, F;Marignani, PA;Yaffe, MB
通讯作者：
Yaffe, MB