The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.
The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.
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DOI：
10.1016/j.drudis.2013.05.015
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发表时间：
2013-08
影响因子：
7.4
通讯作者：
Xia, Menghang
中科院分区：
文献类型：
--
作者：
Attene-Ramos, Matias S.;Miller, Nicole;Huang, Ruili;Michael, Sam;Itkin, Misha;Kavlock, Robert J.;Austin, Christopher P.;Shinn, Paul;Simeonov, Anton;Tice, Raymond R.;Xia, Menghang
自2008年成立以来，美国Tox21机构间合作在开发和评估用于评估环境化学品的细胞模型方面取得了很大进展，作为原则证明。目前，该计划已进入生产阶段（Tox21第二阶段），最初侧重于核受体和应激反应途径的调节领域。在Tox21 Phase II期间，待测化学品已扩展至近10，000（10K）种化合物，并实施了全自动筛选平台。Tox21机器人系统与信息学工作相结合，能够在一周内一式三份地筛选和分析10K环境化学品的集合。在这篇文章中，我们描述了Tox21筛选过程，化合物库制备，数据处理和机器人系统验证。
Since its establishment in 2008, the US Tox21 inter-agency collaboration has made great progress in developing and evaluating cellular models for the evaluation of environmental chemicals as a proof of principle. Currently, the program has entered its production phase (Tox21 Phase II) focusing initially on the areas of modulation of nuclear receptors and stress response pathways. During Tox21 Phase II, the set of chemicals to be tested has been expanded to nearly 10,000 (10K) compounds and a fully automated screening platform has been implemented. The Tox21 robotic system combined with informatics efforts is capable of screening and profiling the collection of 10K environmental chemicals in triplicate in a week. In this article, we describe the Tox21 screening process, compound library preparation, data processing, and robotic system validation.
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DOI：
10.2174/1875397301004010057
发表时间：
2010-10-21
期刊：
Current chemical genomics
影响因子：
--
作者：
Wang Y;Jadhav A;Southal N;Huang R;Nguyen DT
通讯作者：
Nguyen DT
DOI：
10.1080/10937404.2010.483176
发表时间：
2010-02
期刊：
Journal of toxicology and environmental health. Part B, Critical reviews
影响因子：
--
作者：
Krewski D;Acosta D Jr;Andersen M;Anderson H;Bailar JC 3rd;Boekelheide K;Brent R;Charnley G;Cheung VG;Green S Jr;Kelsey KT;Kerkvliet NI;Li AA;McCray L;Meyer O;Patterson RD;Pennie W;Scala RA;Solomon GM;Stephens M;Yager J;Zeise L
通讯作者：
Zeise L
影响因子：
3.6
作者：
Martin, Matthew T.;Knudsen, Thomas B.;Dix, David J.
通讯作者：
Dix, David J.
影响因子：
10.4
作者：
Huang R;Xia M;Cho MH;Sakamuru S;Shinn P;Houck KA;Dix DJ;Judson RS;Witt KL;Kavlock RJ;Tice RR;Austin CP
通讯作者：
Austin CP
影响因子：
10.4
作者：
Tice RR;Austin CP;Kavlock RJ;Bucher JR
通讯作者：
Bucher JR