Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats.
Pharmacological activation of kappa opioid receptors: aversive effects in adolescent and adult male rats.
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DOI：
10.1007/s00213-013-3095-8
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发表时间：
2014-04
影响因子：
3.4
通讯作者：
Varlinskaya, Elena I.
中科院分区：
文献类型：
--
作者：
Anderson, Rachel I.;Morales, Melissa;Spear, Linda P.;Varlinskaya, Elena I.
关键词：
运动啡(DYN)/kappa阿片受体（KOR）系统参与药物滥用的烦躁特性。鉴于青少年对许多药物的不良反应表现出较低的敏感性，DYN/KOR系统的改变可能有助于青少年吸毒的流行。本研究旨在评估选择性卡帕激动剂u62066在青少年和成年大鼠中的烦躁特性，采用条件味觉厌恶（CTA）和条件地方厌恶（CPA）两种范式。对于CTA，水限制大鼠在获得糖精溶液30分钟后给予U62,066，随后使用糖精消耗量来衡量厌恶程度。对于CPA，动物被允许进入两室室的两个隔间进行15分钟的预处理和后适应测试。作为条件反射，受试者在坐月子前被给予U62,066，在坐月子前被给予生理盐水，共四对。总的来说，与成人相比，青少年对kappa激动剂的敏感性降低。成年人对0.2和0.3 mg/kg剂量的u62066表现出味觉厌恶，而青少年对任何测试剂量都没有表现出厌恶。成人对0.1和0.2 mg/kg剂量的u62066与调节室的首选侧配对时表现出厌恶。青少年对任何一种测试剂量都没有表现出厌恶。青少年对DYN/KOR系统激活的敏感性降低，可能是青少年对常用药物的厌恶特性不敏感的一个原因。
The dynorphin (DYN)/kappa opioid receptor (KOR) system is involved in the dysphoric properties of drugs of abuse. Given that adolescents show reduced sensitivity to aversive effects of many drugs, alterations in the DYN/KOR system may contribute to the prevalence of drug use during adolescence. The present study was designed to assess dysphoric properties of a selective kappa agonist, U62,066, in adolescent and adult rats using both conditioned taste aversion (CTA) and conditioned place aversion (CPA) paradigms. For CTA, water-restricted rats were administered U62,066 following 30 min access to a saccharin solution, with subsequent saccharin consumption used to index aversion. For CPA, animals were allowed access to both compartments of a two-compartment chamber for a 15-minute pre- and post-conditioning test. For conditioning, subjects were administered U62,066 prior to confinement to one side of the chamber and saline prior to confinement to the other side for a total of four pairings. Overall, adolescents displayed reduced sensitivity to the kappa agonist relative to adults. Adults demonstrated taste aversions to the 0.2 and 0.3 mg/kg doses of U62,066 whereas adolescents did not display aversions to any tested doses. Adults demonstrated a place aversion to the 0.1 and 0.2 mg/kg dose of U62,066 when paired with the preferred side of the conditioning chamber. Adolescents did not display aversions to any of the doses tested. Reduced sensitivity to DYN/KOR system activation during adolescence may be a contributing factor to the age-typical insensitivity to aversive properties of drugs commonly abused by adolescents.
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影响因子：
3.4
作者：
BARR, GA;WANG, SN;CARDEN, S
通讯作者：
CARDEN, S
影响因子：
3.4
作者：
BALSKUBIK, R;HERZ, A;SHIPPENBERG, TS
通讯作者：
SHIPPENBERG, TS
影响因子：
2.3
作者：
Nizhnikov, Michael E.;Marcos Pautassi, Ricardo;Spear, Norman E.
通讯作者：
Spear, Norman E.
影响因子：
3.3
作者：
Anderson RI;Agoglia AE;Morales M;Varlinskaya EI;Spear LP
通讯作者：
Spear LP
DOI：
10.1196/annals.1308.003
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Kelley, AE;Schochet, T;Landry, CF
通讯作者：
Landry, CF