Animal models of axon regeneration after spinal cord injury.

Animal models of axon regeneration after spinal cord injury.
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DOI:
10.1007/s12264-013-1365-4
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发表时间:
2013-08
影响因子:
5.6
通讯作者:
Lee, Jae K.
Lee, Jae K.
中科院分区:
医学2区
文献类型:
--
作者:
Lee, Do-Hun;Lee, Jae K.

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随着遗传和成像技术的进步,研究脊髓损伤后轴突再生在体内变得越来越普遍。然而,在使用轴突再生动物模型时,有许多问题需要考虑,包括物种、品系和损伤模型。没有一种特定的模型适合所有类型的实验,每一个假设都需要仔细选择合适的动物模型。本文综述了几种常用的脊髓轴突再生动物模型,并讨论了它们的优缺点。
With advances in genetic and imaging techniques, investigating axon regeneration after spinal cord injury in vivo is becoming more common in the literature. However, there are many issues to consider when using animal models of axon regeneration, including species, strains and injury models. No single particular model suits all types of experiments and each hypothesis being tested requires careful selection of the appropriate animal model. In this review, we describe several commonly-used animal models of axon regeneration in the spinal cord and discuss their advantages and disadvantages.
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