Uterine diseases in cattle after parturition.
Uterine diseases in cattle after parturition.
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DOI：
10.1016/j.tvjl.2007.12.031
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发表时间：
2008-04
期刊：
影响因子：
--
通讯作者：
Herath S
中科院分区：
文献类型：
--
作者：
Sheldon IM;Williams EJ;Miller AN;Nash DM;Herath S
子宫腔的细菌污染在牛分娩后很常见，常常导致感染和子宫疾病。临床疾病可以通过检查阴道粘液来诊断和评分，这反映了大肠杆菌和化脓秘杆菌等致病菌的存在。病毒也可能引起子宫疾病，牛疱疹病毒 4 (BoHV-4) 嗜向子宫内膜细胞，引起快速细胞病变效应。先天免疫系统消除病原体依赖于结合病原体相关分子的模式识别受体。子宫上皮细胞和基质细胞表达受体，例如结合大肠杆菌脂多糖的 Toll 样受体 4。与子宫疾病相关的不孕症是由子宫内膜损伤和卵巢周期活动破坏引起的。细菌调节子宫内膜前列腺素分泌，并扰乱卵泡的生长和功能。了解子宫疾病的分子基础将带来治疗不孕症的新方法。
Bacterial contamination of the uterine lumen is common in cattle after parturition, often leading to infection and uterine disease. Clinical disease can be diagnosed and scored by examination of the vaginal mucus, which reflects the presence of pathogenic bacteria such as Escherichia coli and Arcanobacterium pyogenes. Viruses may also cause uterine disease and bovine herpesvirus 4 (BoHV-4) is tropic for endometrial cells, causing a rapid cytopathic effect. The elimination of pathogens by the innate immune system is dependent on pattern recognition receptors binding pathogen-associated molecules. Uterine epithelial and stromal cells express receptors such as Toll-like Receptor 4 that binds E. coli lipopolysaccharide. The infertility associated with uterine disease is caused by damage to the endometrium and disruption of ovarian cyclic activity. Bacteria modulate endometrial prostaglandin secretion, and perturb ovarian follicle growth and function. Understanding the molecular basis of uterine disease will lead to novel approaches to treating infertility.
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影响因子：
3.6
作者：
Beam, SW;Butler, WR
通讯作者：
Butler, WR
影响因子：
2.8
作者：
GRIFFIN J F T;HARTIGAN P J;NUNN W R
通讯作者：
NUNN W R
影响因子：
5.8
作者：
Hirata, T;Osuga, Y;Taketani, Y
通讯作者：
Taketani, Y
DOI：
10.1136/vr.161.20.695
发表时间：
2007-11-17
期刊：
The Veterinary record
影响因子：
--
作者：
Grant E;Lilly ST;Herath S;Sheldon IM
通讯作者：
Sheldon IM
影响因子：
1.8
作者：
Connor, Erin E.;Cates, Elizabeth A.;Bannerman, Douglas D.
通讯作者：
Bannerman, Douglas D.