Regulation of senescence by microRNA biogenesis factors.
Regulation of senescence by microRNA biogenesis factors.
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DOI：
10.1016/j.arr.2012.01.003
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发表时间：
2012-09
影响因子：
13.1
通讯作者：
Gorospe, Myriam
中科院分区：
文献类型：
--
作者：
Abdelmohsen, Kotb;Srikantan, Subramanya;Kang, Min-Ju;Gorospe, Myriam
衰老代表细胞中无限期生长停滞的状态，这些细胞已经达到其复制寿命，已经受损，或表达异常水平的癌症相关蛋白。虽然衰老被广泛认为代表肿瘤抑制机制，但衰老细胞在老年生物体组织中的积累被认为是生理功能和年龄相关疾病中年龄相关损失的基础。随着microRNA（miRNAs）作为衰老的主要分子调节因子的出现，我们综述了控制衰老相关microRNA生物合成的转录和转录后因子。重点是它们对衰老的增强或抑制，我们描述了控制初级（pri-）miRNA合成的转录因子，控制pri-miRNA核加工成前体（pre-）miRNA的蛋白质，包括RNA编辑酶，RNA酶和RNA解旋酶，以及影响pre-miRNA最终加工成成熟miRNA的细胞质蛋白。我们讨论了miRNA生物发生蛋白如何增强或抑制衰老，从而影响衰老表型，影响正常组织功能和病理。
Senescence represents a state of indefinite growth arrest in cells that have reached their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent tumor-suppressive mechanism, the accumulation of senescent cells in tissues of older organisms is believed to underlie age-associated losses in physiologic function and age-related diseases. With the emergence of microRNAs (miRNAs) as a major class of molecular regulators of senescence, we review the transcriptional and post-transcriptional factors that control senescence-associated microRNA biosynthesis. Focusing on their enhancement or repression of senescence, we describe the transcription factors that govern the synthesis of primary (pri-)miRNAs, the proteins that control the nuclear processing of pri-miRNAs into precursor (pre-)miRNAs, including RNA editing enzymes, RNases, and RNA helicases, and the cytoplasmic proteins that affect the final processing of pre-miRNAs into mature miRNAs. We discuss how miRNA biogenesis proteins enhance or repress senescence, and thus influence the senescent phenotype that affects normal tissue function and pathology.
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