Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.
Predicting the Influence of Axon Myelination on Sound Localization Precision Using a Spiking Neural Network Model of Auditory Brainstem.
复制标题
DOI：
10.3389/fnins.2022.840983
复制
发表时间：
2022
影响因子：
4.3
通讯作者：
Klug A
中科院分区：
文献类型：
--
作者：
Li BZ;Pun SH;Vai MI;Lei TC;Klug A
空间听觉使动物能够快速检测和定位周围环境中的听觉事件。听觉脑干在通过微秒级精确的双耳整合处理和提取双耳空间线索方面发挥着核心作用，特别是在检测内侧上橄榄（MSO）低频声音的耳间时间差（ITD）方面。底层神经回路中存在一系列机制，用于保持沿该通路的多个纤维、突触和细胞核的准确动作电位计时。其中之一是传入纤维的髓鞘化，确保轴突中可靠且时间精确的动作电位传播。有一些关于 MSO 回路中髓鞘形成模式微调的报道，但髓鞘形成如何具体影响声音定位的精度仍不完全清楚。在这里，我们提出了带有髓鞘轴突的蒙古沙鼠听觉脑干的尖峰神经网络（SNN）模型，以研究不同的轴突髓鞘化厚度是否会改变声音定位过程。我们的模型表明，沿对侧通路的轴突髓鞘厚度可以显着调节 ITD 检测。此外，与对侧激发相比，当 MSO 通过较厚的有髓轴突接受对侧抑制时，可以达到最佳的 ITD 灵敏度，这一结果与之前报道的实验观察结果一致。我们的结果表明轴突髓鞘化在 ITD 解码中提取时间动态方面的特定作用，特别是在对侧抑制途径中。
Spatial hearing allows animals to rapidly detect and localize auditory events in the surrounding environment. The auditory brainstem plays a central role in processing and extracting binaural spatial cues through microsecond-precise binaural integration, especially for detecting interaural time differences (ITDs) of low-frequency sounds at the medial superior olive (MSO). A series of mechanisms exist in the underlying neural circuits for preserving accurate action potential timing across multiple fibers, synapses and nuclei along this pathway. One of these is the myelination of afferent fibers that ensures reliable and temporally precise action potential propagation in the axon. There are several reports of fine-tuned myelination patterns in the MSO circuit, but how specifically myelination influences the precision of sound localization remains incompletely understood. Here we present a spiking neural network (SNN) model of the Mongolian gerbil auditory brainstem with myelinated axons to investigate whether different axon myelination thicknesses alter the sound localization process. Our model demonstrates that axon myelin thickness along the contralateral pathways can substantially modulate ITD detection. Furthermore, optimal ITD sensitivity is reached when the MSO receives contralateral inhibition via thicker myelinated axons compared to contralateral excitation, a result that is consistent with previously reported experimental observations. Our results suggest specific roles of axon myelination for extracting temporal dynamics in ITD decoding, especially in the pathway of the contralateral inhibition.
登录
查看更多内容
兴奋性和兴奋前抑制诱导的增强神经元反应的阈值机制
影响因子：
3.1
作者：
Ma H;Jia B;Li Y;Gu H
通讯作者：
Gu H
影响因子：
4.3
作者：
Lucas A;Poleg S;Klug A;McCullagh EA
通讯作者：
McCullagh EA
影响因子：
3.5
作者：
Grothe B;Pecka M
通讯作者：
Pecka M
DOI：
10.1037/h0061495
发表时间：
1948-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
JEFFRESS, LA
通讯作者：
JEFFRESS, LA
影响因子：
2.5
作者：
GOLDBERG, JM;BROWN, PB
通讯作者：
BROWN, PB