Genetic associations with a fever after measles-containing vaccines.
Genetic associations with a fever after measles-containing vaccines.
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接种含麻疹疫苗后发烧与遗传相关。
DOI：
10.1080/21645515.2020.1849520
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发表时间：
2021-06-03
影响因子：
4.8
通讯作者：
Gans HA
中科院分区：
文献类型：
--
作者：
Klein NP;Zerbo O;Goddard K;Wang W;Fohner AE;Wiesner A;Shokoohi V;Coller J;Bok K;Gans HA
儿童在接种第一剂麻疹疫苗(MCV)后1至2周发烧风险增加，这可能受到遗传、免疫学和临床因素的影响。MCV后发热与热性惊厥有关，但也可能与较高的麻疹抗体效价有关。这项探索性研究调查了遗传和免疫学与MCV后发热的关系。在一项随机的第三阶段临床试验中，12-15个月大的婴儿接种了他们的第一个麻疹-腮腺炎-风疹(MMR)疫苗，在该试验中，父母每天记录接种后的温度，同时我们同意收集额外的血液并进行人类白细胞抗原(HLA)配型。用Logistic回归分析MMR后5-12天发热(“MMR相关”)与HLA型的关系。我们用t检验比较了接种疫苗后42天几何平均滴度(GMT)与麻疹之间有无发烧的儿童之间的差异。我们招募了86名儿童，对82名儿童进行了HLA配型；13名(15.1%)有MMR相关发热。Logistic回归分析表明，MMR相关发热与HLAI类基因座A-29：02(P=10.036)、B-57：01(P=0.018)、C-06：02(P=0.006)、C-14：02(P=0.022)和II类基因座DRB1-15(P=6.045)相关。然而，Bonferroni对多重比较的调整表明，这些联系可能是偶然的。98%的儿童具有麻疹保护性抗体效价；然而，发热者的GMT高于非发热者(P=0.006)。麻疹疫苗接种后发热与遗传因素和较高的免疫应答有关。这项研究表明，MMR相关发热可能存在遗传易感性。
Children have elevated fever risk 1 to 2 weeks after the first dose of a measles-containing vaccine (MCV), which is likely affected by genetic, immunologic, and clinical factors. Fever after MCV is associated with febrile seizures, though may also be associated with higher measles antibody titers. This exploratory study investigated genetic and immunologic associations with a fever after MCV. Concurrent with a randomized Phase 3 clinical trial of 12–15-month-olds who received their first measles-mumps-rubella (MMR) vaccine in which parents recorded post-vaccination temperatures daily, we consented a subset to collect additional blood and performed human leukocyte antigens (HLA) typing. Association between fever 5–12 days after MMR (“MMR-associated”) and HLA type was assessed using logistic regression. We compared 42-day post-vaccination geometric mean titers (GMT) to measles between children who did and did not have fever using a t-test. We enrolled 86 children and performed HLA typing on 82; 13 (15.1%) had MMR-associated fever. Logistic regressions identified associations between MMR-associated fever and HLA Class I loci A-29:02 (P = .036), B-57:01 (P = .018), C-06:02 (P = .006), C-14:02 (P = .022), and Class II loci DRB1-15 (P = .045). However, Bonferroni's adjustment for multiple comparisons suggests that these associations could have been due to chance. Ninety-eight percent of children had protective antibody titers to measles; however, GMT was higher among those with fever compared with children without fever (P = .006). Fever after the measles vaccine correlated with genetic factors and higher immune response. This study suggests a possible genetic susceptibility to MMR-associated fever.
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CD46 和 IFI44L 基因变异与麻疹疫苗中和抗体反应的全基因组关联。
影响因子：
5.3
作者：
Haralambieva IH;Ovsyannikova IG;Kennedy RB;Larrabee BR;Zimmermann MT;Grill DE;Schaid DJ;Poland GA
通讯作者：
Poland GA
影响因子：
5.5
作者：
Klein, Nicola P.;Shepard, Julie;Dull, Peter
通讯作者：
Dull, Peter
影响因子：
5.5
作者：
Ovsyannikova, Inna G.;Jacobson, Robert M.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.
影响因子：
0.9
作者：
Mayo, Oliver
通讯作者：
Mayo, Oliver
影响因子：
1.8
作者：
Ovsyannikova, Inna G.;Haralambieva, Iana H.;Poland, Gregory A.
通讯作者：
Poland, Gregory A.