Anatomical substrates and connectivity for bradykinesia motor features in Parkinson's disease after subthalamic nucleus deep brain stimulation.
Anatomical substrates and connectivity for bradykinesia motor features in Parkinson's disease after subthalamic nucleus deep brain stimulation.
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DOI：
10.1093/braincomms/fcad337
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发表时间：
2023
影响因子：
4.8
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中科院分区：
文献类型：
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帕金森运动迟缓的评分采用复合量表，包括重复运动的缓慢频率、衰减幅度和心律失常。这些运动成分在基底神经节内的不同定位将推动更个性化的网络靶向对症治疗的发展。在这项研究中，我们使用光学运动传感器，评估了15名帕金森病患者在丘脑下核深部脑刺激“开启”或“关闭”的抓取任务中手部运动的幅度和频率。运动迟缓的严重程度采用统一帕金森病评定第三部分量表进行盲法评估。每个受试者的激活组织的体积被估计，其中振幅和频率的变化被绘制出来，以确定丘脑下核中每个成分的不同解剖底物。激活组织的体积被用来培育一个规范的功能连接组，以生成与振幅和频率变化相关的连接图。脑深部刺激引起的幅度变化与统一帕金森病评定第三部分量表右手（r = - 0.65, P < 0.05）和左手抓握评分变化呈负相关（r = - 0.63, P < 0.05）。右手（r = - 0.63, P < 0.05）和左手（r = - 0.57, P < 0.05）频率变化与振幅呈负相关。振幅和频率变化表现为空间梯度，重叠和非重叠区域跨越丘脑底核的前内侧-后外侧轴。功能连通性和运动变化之间的全脑相关图也在振幅和频率变化之间反转。深度脑刺激相关的频率和幅度变化在地形学上和明显地表现在局部丘脑下核和全脑功能连接中。Kim等人报道了丘脑下核深部脑刺激诱导的与帕金森病运动迟缓的个体成分相关的组织激活量，显示了与手部运动的幅度和频率相关的单独部位。他们还表明，振幅“甜蜜点”的刺激与运动等级量表的变化密切相关。
Parkinsonian bradykinesia is rated using a composite scale incorporating the slowed frequency of repetitive movements, decrement amplitude and arrhythmicity. Differential localization of these movement components within the basal ganglia will drive the development of more personalized network-targeted symptomatic therapies. In this study, using an optical motion sensor, we evaluated the amplitude and frequency of hand movements during a grasping task with subthalamic nucleus deep brain stimulation ‘on’ or ‘off’ in 15 patients with Parkinson’s disease. The severity of bradykinesia was assessed blindly using the Unified Parkinson’s Disease Rating Part III scale. The volumes of activated tissue of each subject were estimated where changes in amplitude and frequency were mapped to identify distinct anatomical substrates of each component in the subthalamic nucleus. The volumes of activated tissue were used to seed a normative functional connectome to generate connectivity maps associated with amplitude and frequency changes. Deep brain stimulation–induced change in amplitude was negatively correlated with a change in Unified Parkinson’s Disease Rating Part III scale for right (r = −0.65, P < 0.05) and left hand grasping scores (r = −0.63, P < 0.05). The change in frequency was negatively correlated with amplitude for both right (r = −0.63, P < 0.05) and left hands (r = −0.57, P < 0.05). The amplitude and frequency changes were represented as a spatial gradient with overlapping and non-overlapping regions spanning the anteromedial–posterolateral axis of the subthalamic nucleus. Whole-brain correlation maps between functional connectivity and motor changes were also inverted between amplitude and frequency changes. Deep brain stimulation–associated changes in frequency and amplitude were topographically and distinctly represented both locally in the subthalamic nucleus and in whole-brain functional connectivity. Kim et al. report on subthalamic nucleus deep brain stimulation–induced volumes of tissue activation associated with individual components of Parkinson’s disease bradykinesia, showing separate sites associated with the amplitude and frequency of hand movements. They also show that the stimulation of the amplitude ‘sweetspot’ correlates most strongly with changes in motor rating scales.
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影响因子：
9.8
作者：
Holmes, Avram J.;Hollinshead, Marisa O.;O'Keefe, Timothy M.;Petrov, Victor I.;Fariello, Gabriele R.;Wald, Lawrence L.;Fischl, Bruce;Rosen, Bruce R.;Mair, Ross W.;Roffman, Joshua L.;Smoller, Jordan W.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
8.6
作者：
Heldman, Dustin A.;Giuffrida, Joseph P.;Chen, Robert;Payne, Megan;Mazzella, Filomena;Duker, Andrew P.;Sahay, Alok;Kim, Sang Jin;Revilla, Fredy J.;Espay, Alberto J.
通讯作者：
Espay, Alberto J.
影响因子：
1.7
作者：
Astrom, Mattias;Tripoliti, Elina;Wardell, Karin
通讯作者：
Wardell, Karin
影响因子：
11
作者：
Bot, Maarten;Schuurman, P. Richard;van den Munckhof, Pepijn
通讯作者：
van den Munckhof, Pepijn
影响因子：
4.3
作者：
Loh, Aaron;Boutet, Alexandre;Germann, Jurgen;Al-Fatly, Bassam;Elias, Gavin J. B.;Neudorfer, Clemens;Krotz, Jillian;Wong, Emily H. Y.;Parmar, Roohie;Gramer, Robert;Paff, Michelle;Horn, Andreas;Chen, J. Jean;Azevedo, Paula;Fasano, Alfonso;Munhoz, Renato P.;Hodaie, Mojgan;Kalia, Suneil K.;Kucharczyk, Walter;Lozano, Andres M.
通讯作者：
Lozano, Andres M.