Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review.
Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review.
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揭开5-羟色胺传奇：从发现到体重调节和超越--一篇全面的科学评论。
DOI：
10.1186/s13578-023-01091-7
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发表时间：
2023-08-07
影响因子：
7.5
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Conde, Kristine;Fang, Shuzheng;Xu, Yong
肥胖在全球的患病率迅速上升，然而有效的肥胖治疗方法的研发却滞后。尽管每天都有新的减轻肥胖的治疗靶点被发现，且药物疗效在提高，但不良副作用以及增加的健康风险仍然是减肥行业面临的严重问题。血清素，也被称为5 - 羟色胺（5 - HT），在食欲降低和减肥方面已被广泛研究。结果，5 - HT的数十个上下游神经靶点已被确定，揭示了众多参与介导5 - HT厌食作用的神经回路。尽管近几十年来几种5 - HT疗法有起有落，但5 - HT作为减肥治疗的一个治疗靶点的未来看起来很有希望。这篇综述聚焦于血清素的历史、当前中枢血清素研究的状况、以往的血清素能疗法以及血清素在治疗肥胖个体方面的未来。
The prevalence of obesity is rapidly increasing worldwide, while the development of effective obesity therapies lags behind. Although new therapeutic targets to alleviate obesity are identified every day, and drug efficacy is improving, adverse side effects and increased health risks remain serious issues facing the weight-loss industry. Serotonin, also known as 5-HT, has been extensively studied in relation to appetite reduction and weight loss. As a result, dozens of upstream and downstream neural targets of 5-HT have been identified, revealing a multitude of neural circuits involved in mediating the anorexigenic effect of 5-HT. Despite the rise and fall of several 5-HT therapeutics in recent decades, the future of 5-HT as a therapeutic target for weight-loss therapy looks promising. This review focuses on the history of serotonin, the state of current central serotonin research, previous serotonergic therapies, and the future of serotonin for treating individuals with obesity.
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影响因子：
8.1
作者：
Burke LK;Ogunnowo-Bada E;Georgescu T;Cristiano C;de Morentin PBM;Valencia Torres L;D'Agostino G;Riches C;Heeley N;Ruan Y;Rubinstein M;Low MJ;Myers MG;Rochford JJ;Evans ML;Heisler LK
通讯作者：
Heisler LK
影响因子：
2.9
作者：
De Fanti, BA;Hamilton, JS;Horwitz, BA
通讯作者：
Horwitz, BA
影响因子：
25
作者：
Cai, Xing;Liu, Hailan;Feng, Bing;Yu, Meng;He, Yang;Liu, Hesong;Liang, Chen;Yang, Yongjie;Tu, Longlong;Zhang, Nan;Wang, Lina;Yin, Na;Han, Junying;Yan, Zili;Wang, Chunmei;Xu, Pingwen;Wu, Qi;Tong, Qingchun;He, Yanlin;Xu, Yong
通讯作者：
Xu, Yong
影响因子：
158.5
作者：
Connolly, HM;Crary, JL;Schaff, HV
通讯作者：
Schaff, HV
影响因子：
3.4
作者：
Bäckberg, M;Hervieu, G;Meister, B
通讯作者：
Meister, B