Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.
Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.
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DOI：
10.3390/cancers9070091
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发表时间：
2017-07-18
期刊：
影响因子：
5.2
通讯作者：
Georgakilas AG
中科院分区：
文献类型：
--
作者：
Mavragani IV;Nikitaki Z;Souli MP;Aziz A;Nowsheen S;Aziz K;Rogakou E;Georgakilas AG
电离辐射对细胞的影响多种多样，程度也很高，但主要是破坏性的，因为辐射可扰乱细胞的所有重要组成部分，从细胞膜到细胞核，这是由于从脂质到蛋白质或DNA的不同生物分子发生改变。关于DNA损伤，这是本次审查的主要焦点，以及它的修复，所有目前的知识表明，IR诱导的DNA损伤总是比相应的内源性氧化应激造成的内源性损伤更复杂。具体地，预期IR将产生由多种DNA损伤组成的损伤簇，如双链断裂（DSB）、单链断裂（SSB）和在高达15-20 bp的短DNA区域内的碱基损伤。来自我们小组和其他人的最新数据支持两个主要概念，即这些受损的簇：（1）修复抗性，增加基因组不稳定性（GI）和恶性转化，（2）可以被认为是促进慢性炎症和免疫反应的持续“危险”信号，对生物体造成有害影响（如辐射毒性）。最后但并非最不重要的是，辐射诱导的全身效应的作用的范式转变也被纳入这一复杂的DNA损伤诱导及其错误修复的IR效应和后果的图片。
Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs), single strand breaks (SSBs) and base lesions within a short DNA region of up to 15–20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1) repair resistant, increasing genomic instability (GI) and malignant transformation and (2) can be considered as persistent “danger” signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity). Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair.
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影响因子：
3.8
作者：
Banáth JP;Klokov D;MacPhail SH;Banuelos CA;Olive PL
通讯作者：
Olive PL
DOI：
10.1073/pnas.131077798
发表时间：
2001-06-19
影响因子：
11.1
作者：
Blaisdell, JO;Wallace, SS
通讯作者：
Wallace, SS
DOI：
10.1073/pnas.1016045108
发表时间：
2011-05-17
影响因子：
11.1
作者：
Asaithamby, Aroumougame;Hu, Burong;Chen, David J.
通讯作者：
Chen, David J.
影响因子：
1
作者：
Brabcova, K. Pachnerova;Stepan, V.;Sihver, L.
通讯作者：
Sihver, L.
影响因子：
2.6
作者：
Cox, R
通讯作者：
Cox, R