The diversity and plasticity of adult hepatic progenitor cells and their niche.
The diversity and plasticity of adult hepatic progenitor cells and their niche.
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成体肝祖细胞及其生态位的多样性和可塑性
DOI：
10.1111/liv.13377
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Duan Y
中科院分区：
文献类型：
--
作者：
Chen J;Chen L;Zern MA;Theise ND;Diehl AM;Liu P;Duan Y
肝脏是一个独特的具有再生能力的动态平衡器官。肝细胞在损伤后具有显著的增殖能力；然而，在更严重的情况下，肝再生被认为是至少一个，如果不是几个兼性肝祖细胞隔室的话。新发现的中心周围干/祖细胞位于中央静脉周围，负责维持未受损伤肝脏的肝细胞内稳态。此外，据报道，肝祖细胞与肝纤维化和癌症有关。驱动肝脏内稳态、再生和疾病的因素是由生理和病理条件决定的，特别是影响肝祖细胞命运的肝祖细胞生态位。肝祖细胞生态位是由不同细胞类型、释放生长因子和细胞因子、接受信号以及细胞外基质(ECM)支架组成的特殊微环境。肝脏祖细胞壁龛维持和调节干细胞，以确保器官的稳态和再生。近年来的研究表明，肝细胞、胆管细胞或肌成纤维细胞等肝细胞在一定条件下可通过转化诱导为类卵圆细胞状态，这些细胞类型作为潜在的肝祖细胞在肝脏病理生理过程中发挥着重要作用。在这篇综述中，我们描述和更新了肝祖细胞的多样性和可塑性及其生态位的最新进展，并讨论了支持它们在肝脏稳态、再生、纤维化和癌症中的作用的证据。
The liver is a unique organ for homoeostasis with regenerative capacities. Hepatocytes possess a remarkable capacity to proliferate upon injury; however, in more severe scenarios liver regeneration is believed to arise from at least one, if not several facultative hepatic progenitor cell compartments. Newly identified pericentral stem/progenitor cells residing around the central vein is responsible for maintaining hepatocyte homoeostasis in the uninjured liver. In addition, hepatic progenitor cells have been reported to contribute to liver fibrosis and cancers. What drives liver homoeostasis, regeneration and diseases is determined by the physiological and pathological conditions, and especially the hepatic progenitor cell niches which influence the fate of hepatic progenitor cells. The hepatic progenitor cell niches are special microenvironments consisting of different cell types, releasing growth factors and cytokines and receiving signals, as well as the extracellular matrix (ECM) scaffold. The hepatic progenitor cell niches maintain and regulate stem cells to ensure organ homoeostasis and regeneration. In recent studies, more evidence has been shown that hepatic cells such as hepatocytes, cholangiocytes or myofibroblasts can be induced to be oval cell‐like state through transitions under some circumstance, those transitional cell types as potential liver‐resident progenitor cells play important roles in liver pathophysiology. In this review, we describe and update recent advances in the diversity and plasticity of hepatic progenitor cell and their niches and discuss evidence supporting their roles in liver homoeostasis, regeneration, fibrosis and cancers.
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DOI：
10.1152/ajpgi.00069.2014
发表时间：
2015-02-15
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Dollé L;Theise ND;Schmelzer E;Boulter L;Gires O;van Grunsven LA
通讯作者：
van Grunsven LA
影响因子：
10.5
作者：
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通讯作者：
Grompe, Markus
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.6
作者：
BISGAARD, HC;PARMELEE, DC;THORGEIRSSON, SS
通讯作者：
THORGEIRSSON, SS
影响因子：
3.7
作者：
Chen J;Zhang X;Xu Y;Li X;Ren S;Zhou Y;Duan Y;Zern M;Zhang H;Chen G;Liu C;Mu Y;Liu P
通讯作者：
Liu P