Prognostic role of Wnt and Fzd gene families in acute myeloid leukaemia.
Prognostic role of Wnt and Fzd gene families in acute myeloid leukaemia.
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Wnt和Fzd基因家族在急性髓系白血病中的预后作用
DOI：
10.1111/jcmm.16233
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发表时间：
2021-03
影响因子：
5.3
通讯作者：
Zeng T
中科院分区：
文献类型：
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作者：
Dai Y;Cheng Z;Fricke DR;Zhao H;Huang W;Zhong Q;Zhu P;Zhang W;Wu Z;Lin Q;Zhu H;Liu Y;Qian T;Fu L;Cui L;Zeng T
Wnt-Fzd 信号通路在急性髓系白血病 (AML) 进展和致癌性中发挥着关键作用。目前尚无研究探讨 Wnt 和 Fzd 基因家族在 AML 中的预后价值。我们的研究从癌症基因组图谱 (TCGA) 数据库中筛选了 84 名仅接受化疗的 AML 患者和 71 名同时接受同种异体造血干细胞移植 (allo-HSCT) 的患者。我们发现一些Wnt和Fzd基因具有显着的正相关性。 Fzd 基因家族的表达水平与 AML 患者的生存率无关。在化疗组中，Wnt2B或Wnt11高表达的AML患者的无事件生存期（EFS）和总生存期（OS）显着缩短； Wnt10A 高表达者的 OS 显着长于低表达者（所有 P < .05），而在异基因 HSCT 组中，Wnt 基因家族的表达水平与生存无关。我们进一步发现Wnt10A和Wnt11的高表达具有独立的预后价值，并且Wnt10A高表达和Wnt11低表达的患者在化疗组中具有最长的EFS和OS。通路富集分析显示，Wnt10A、Wnt11和Wnt 2B相关基因主要富集于“参与分化的细胞形态发生”、“造血细胞谱系”、“血小板激活、信号传导和聚集”和“线粒体RNA代谢过程”信号通路。我们的结果表明，Wnt2B 和 Wnt11 高表达预示着 AML 预后不良，Wnt10A 高表达预示着 AML 预后良好，但它们的预后影响可以通过异基因 HSCT 来抵消。 Wnt10A 和 Wnt11 组合可能是 AML 的新预后标志物。
Wnt‐Fzd signalling pathway plays a critical role in acute myeloid leukaemia (AML) progression and oncogenicity. There is no study to investigate the prognostic value of Wnt and Fzd gene families in AML. Our study screened 84 AML patients receiving chemotherapy only and 71 also undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT) from the Cancer Genome Atlas (TCGA) database. We found that some Wnt and Fzd genes had significant positive correlations. The expression levels of Fzd gene family were independent of survival in AML patients. In the chemotherapy group, AML patients with high Wnt2B or Wnt11 expression had significantly shorter event‐free survival (EFS) and overall survival (OS); high Wnt10A expressers had significantly longer OS than the low expressers (all P < .05), whereas, in the allo‐HSCT group, the expression levels of Wnt gene family were independent of survival. We further found that high expression of Wnt10A and Wnt11 had independent prognostic value, and the patients with high Wnt10A and low Wnt11 expression had the longest EFS and OS in the chemotherapy group. Pathway enrichment analysis showed that genes related to Wnt10A, Wnt11 and Wnt 2B were mainly enriched in ‘cell morphogenesis involved in differentiation’, ‘haematopoietic cell lineage’, ‘platelet activation, signalling and aggregation’ and ‘mitochondrial RNA metabolic process’ signalling pathways. Our results indicate that high Wnt2B and Wnt11 expression predict poor prognosis, and high Wnt10A expression predicts favourable prognosis in AML, but their prognostic effects could be neutralized by allo‐HSCT. Combined Wnt10A and Wnt11 may be a novel prognostic marker in AML.
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miR-324-3p 通过靶向 WNT2B 抑制鼻咽癌的迁移和侵袭。
影响因子：
5.8
作者：
Liu C;Li G;Yang N;Su Z;Zhang S;Deng T;Ren S;Lu S;Tian Y;Liu Y;Qiu Y
通讯作者：
Qiu Y
影响因子：
2.9
作者：
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通讯作者：
Zhang, Yongchen
影响因子：
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作者：
Dai, Yifeng;Cheng, Zhiheng;Fu, Lin
通讯作者：
Fu, Lin
影响因子：
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作者：
Barbieri E;Deflorian G;Pezzimenti F;Valli D;Saia M;Meani N;Gruszka AM;Alcalay M
通讯作者：
Alcalay M
影响因子：
3.8
作者：
García-Castro B;Alvarez-Zavala M;Riveros-Magaña AR;Ortíz-Lazareno PC;Ratkovich-González S;Hernández-Flores G;Bravo-Cuellar A;Jave-Suarez LF;Aguilar-Lemarroy A
通讯作者：
Aguilar-Lemarroy A