Ca(2+)/calmodulin-dependent protein kinases.
Ca(2+)/calmodulin-dependent protein kinases.
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DOI：
10.1007/s00018-008-8086-2
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发表时间：
2008-09
影响因子：
8
通讯作者：
Waxham, M. N.
中科院分区：
文献类型：
--
作者：
Swulius, M. T.;Waxham, M. N.
本文综述了钙/钙调蛋白依赖性蛋白激酶。主要关注的是这种多样化酶家族的结构和功能，以及它们活性的优雅调节。对结构进行比较是为了突出它们催化结构域之间以及蛋白激酶 A（激酶结构原型）之间的保守结构。除了审查这些酶的结构和功能之外，还检查了它们发挥中介作用的各种生物过程。最后，通过探索当与 CaM 激酶相互作用时钙与钙调蛋白结合之间存在的相互作用，考虑酶如何在细胞内环境中被激活。
In this article the calcium/calmodulin-dependent protein kinases are reviewed. The primary focus is on the structure and function of this diverse family of enzymes, and the elegant regulation of their activity. Structures are compared in order to highlight the conserved architecture of their catalytic domains with respect to each other as well as protein kinase A, a prototype for kinase structure. In addition to reviewing structure and function in these enzymes, the variety of biological processes for which they play a mediating role are also examined. Finally, how the enzymes become activated in the intracellular setting is considered by exploring the reciprocal interactions that exist between calcium binding to calmodulin when interacting with the CaM-kinases.
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