Redistribution of adipose tissue is associated with left atrial remodeling and dysfunction in patients with atrial fibrillation.
Redistribution of adipose tissue is associated with left atrial remodeling and dysfunction in patients with atrial fibrillation.
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脂肪组织的重新分布与心房颤动患者的左心房重塑和功能障碍相关
DOI：
10.3389/fcvm.2022.969513
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发表时间：
2022
影响因子：
3.6
通讯作者：
Li, Suhua
中科院分区：
文献类型：
--
作者：
Chen, Qian;Chen, Xiuzhen;Wang, Jiafu;Zhong, Junlin;Zhang, Hui;Wu, Bingyuan;Zheng, Zhenda;Xie, Xujing;Zhu, Jieming;Tang, Xixiang;Li, Suhua
关键词：
目的脂肪组织被认为是心房颤动（AF）的重要调节因子。然而，心外膜脂肪组织（EAT）对AF病理生理的影响可能不同于其他脂肪组织。本研究旨在探讨房颤患者不同脂肪组织的分布特点及其与左房重构和功能的关系。方法205例受试者（包括112例房颤患者和93例非房颤患者）。采用彩色多普勒超声测量皮下、腹膜外和腹腔内脂肪组织的厚度。进行心脏CT扫描以测量围绕整个心脏的EAT的平均厚度（total-EAT）和特定区域，包括左心房（LA-EAT）、左心室、右心室、室间沟和房室沟。通过超声心动图测量LA解剖重构和功能，而使用心电图（在AF患者心脏复律或消融后获得）通过P波持续时间和离散度评价电重构。分析不同脂肪组织厚度与左心房重构及功能的关系。结果房颤患者与非房颤患者的皮下、腹膜外和腹腔内脂肪组织厚度相似，与左心房重构和功能障碍无相关性或相关性较弱。然而，与非AF参与者相比，阵发性和持续性AF患者的总EAT厚度显著增加（非房颤vs.阵发性房颤vs.持续性房颤：6.31 ± 0.63 mm vs. 6.76 ± 0.79 mm vs. 7.01 ± 1.18 mm，P < 0.001），与左心房大小、P波时限和离散度呈正相关，与左房射血分数、峰值应变率呈负相关。更有趣的是，房颤患者的EAT厚度在心脏的不同区域并没有均匀增加。与周围其他区域的EAT相比，LA-EAT的积聚更大，并且与LA重构和功能障碍的关系更密切。多因素Logistic回归分析也显示LA-EAT与房颤的存在显著相关（OR = 4.781，95% CI 2.589-8.831，P < 0.001）。结论EAT的积聚和再分布，尤其是左心房周围的EAT，与房颤患者左心房重构和功能障碍有关，而与其他脂肪组织无关。
Objective Adipose tissue is recognized as a crucial regulator of atrial fibrillation (AF). However, the effect of epicardial adipose tissue (EAT) on the pathophysiology of AF might be different from that of other adipose tissues. The purpose of this study was to explore the distribution features of different adipose tissues in AF patients and their relationships with left atrial (LA) remodeling and function. Methods A total of 205 participants (including 112 AF and 93 non-AF patients) were recruited. Color doppler ultrasound was used to measure the thickness of subcutaneous, extraperitoneal, and intra-abdominal adipose tissue. Cardiac CT scan was performed to measure the mean thickness of EAT surrounding the whole heart (total-EAT) and specific regions, including left atrium (LA-EAT), left ventricle, right ventricle, interventricular groove, and atrioventricular groove. LA anatomical remodeling and function were measured by echocardiography, while electrical remodeling was evaluated by P-wave duration and dispersion using Electrocardiography (obtained after cardioversion or ablation in AF patients). Relationship between the thickness of different adipose tissues and LA remodeling and function was analyzed. Results The thickness of subcutaneous, extraperitoneal, and intra-abdominal adipose tissue was similar between AF and non-AF patients, and had no or only weak association with LA remodeling and dysfunction. However, compared to non-AF participants, total-EAT thickness significantly increased in both paroxysmal and persistent AF patients (non-AF vs. paroxysmal AF vs. persistent AF: 6.31 ± 0.63 mm vs. 6.76 ± 0.79 mm vs. 7.01 ± 1.18 mm, P < 0.001), which was positively correlated with the LA size and P-wave duration and dispersion, and negatively correlated with LA ejection fraction and peak strain rate. More interestingly, EAT thickness in AF patients did not increase uniformly in different regions of the heart. Compared to EAT surrounding the other regions, LA-EAT was found to accumulate more greatly, and had a closer relationship to LA remodeling and dysfunction. Multivariate logistic regression analysis also showed that LA-EAT was significantly correlated with the presence of AF (OR = 4.781; 95% CI 2.589–8.831, P < 0.001). Conclusion Rather than other adipose tissues, accumulation and redistribution of EAT, especially surrounding the LA, is associated with LA remodeling and dysfunction in AF patients.
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DOI：
10.1007/s10840-016-0130-9
发表时间：
2016-11-01
影响因子：
1.8
作者：
Takahashi, Keiko;Okumura, Yasuo;Hirayama, Atsushi
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3.5
作者：
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Romanelli, Massimiliano M. Corsi
影响因子：
24
作者：
Mahajan, Rajiv;Lau, Dennis H.;Sanders, Prashanthan
通讯作者：
Sanders, Prashanthan
影响因子：
2.7
作者：
Shinohara T;Shen MJ;Han S;Maruyama M;Park HW;Fishbein MC;Shen C;Chen PS;Lin SF
通讯作者：
Lin SF
DOI：
10.18632/aging.203148
发表时间：
2021-06-04
期刊：
Aging
影响因子：
--
作者：
Chumakova G;Gritsenko O;Gruzdeva O;Dyleva Y
通讯作者：
Dyleva Y