Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain.
Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain.
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DOI：
10.1016/j.neuroimage.2012.03.075
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发表时间：
2012-08-15
期刊：
影响因子：
5.7
通讯作者：
Jenkins BG
中科院分区：
文献类型：
--
作者：
Jenkins BG
功能性磁共振（fMRI）技术，使用各种认知，运动和感官刺激，导致了一场革命的能力，以地图的大脑功能。药物也可用作刺激物以引起血流动力学变化。与用户可控制的刺激相比，用药物刺激具有许多非常不同的后果，最重要的是在刺激和响应的时间过程中，其通常不由实验者控制。因此，这种类型的实验被称为药理学MRI（phMRI）。与传统的功能磁共振成像相比，药物刺激的使用导致了许多有趣的可能性。使用受体特异性配体，可以表征神经递质系统特异性的脑回路。存在测量反映与药物的药代动力学和/或药效学相关的神经递质释放和结合的参数的可能性。还能够测量特定疾病状态下受体的上调和下调。PhMRI可以被描述为一种利用与神经受体刺激相关的自然血液动力学传导的分子成像技术。这提供了一种具有非常高灵敏度的耦合机制，在某些情况下可以与正电子发射断层扫描（PET）相媲美。大量可用的分子不需要放射性标记，这意味着phMRI成为进行药物发现的非常有用的工具。数据和参数将显示phMRI可以提供信息的神经受体信号和功能，补充PET研究产生的静态图片的受体数量和occupancy。
The technique of functional magnetic resonance (fMRI), using various cognitive, motor and sensory stimuli has led to a revolution in the ability to map brain function. Drugs can also be used as stimuli to elicit an hemodynamic change. Stimulation with a pharmaceutical has a number of very different consequences compared to user controllable stimuli, most importantly in the time course of stimulus and response that is not, in general, controllable by the experimenter. Therefore, this type of experiment has been termed pharmacologic MRI (phMRI). The use of a drug stimulus leads to a number of interesting possibilities compared to conventional fMRI. Using receptor specific ligands one can characterize brain circuitry specific to neurotransmitter systems. The possibility exists to measure parameters reflecting neurotransmitter release and binding associated with the pharmacokinetics and/or the pharmacodynamics of drugs. There is also the ability to measure up- and down-regulation of receptors in specific disease states. PhMRI can be characterized as a molecular imaging technique using the natural hemodynamic transduction related to neuro-receptor stimulus. This provides a coupling mechanism with very high sensitivity that can rival positron emission tomography (PET) in some circumstances. The large numbers of molecules available, that do not require a radio-label, means that phMRI becomes a very useful tool for performing drug discovery. Data and arguments will be presented to show that phMRI can provide information on neuro-receptor signaling and function that complements the static picture generated by PET studies of receptor numbers and occupancies.
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影响因子：
3.4
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