Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.
Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.
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DOI：
10.1093/gerona/gly139
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发表时间：
2019-03-14
期刊：
影响因子：
--
通讯作者：
Koch WJ
中科院分区：
文献类型：
--
作者：
de Lucia C;Wallner M;Eaton DM;Zhao H;Houser SR;Koch WJ
心脏病是全球住院和死亡的主要原因，严重影响医疗保健费用。衰老是心脏病的一个重要危险因素，衰老的心脏以结构和功能变化为特征，包括舒张和收缩功能障碍以及左心室（LV）不同步。基于斑点追踪的应变超声心动图（STE）已被证明是一种无创、可重复和高度灵敏的方法，可用于评价动物模型和人体的左心室功能。在这里，我们描述了这种技术的效率作为一个全面的和敏感的方法检测年龄相关的小鼠心功能不全。与传统的超声心动图测量相比，径向和纵向应变，以及反向纵向应变能够检测到微妙的变化，在收缩和舒张心脏功能的小鼠在老化过程中的较早的时间点。此外，数据显示整个LV的径向和纵向轴上的区域收缩力随年龄逐渐且一致地降低。此外，我们观察到左室节段性不同步性在纵轴上可靠地区分老年和年轻小鼠。因此，我们建议使用超声心动图应变作为一种高度敏感和准确的技术，使和评估新的治疗方法的效果，以打击年龄引起的心脏病。
Heart disease is the leading cause of hospitalization and death worldwide, severely affecting health care costs. Aging is a significant risk factor for heart disease, and the senescent heart is characterized by structural and functional changes including diastolic and systolic dysfunction as well as left ventricular (LV) dyssynchrony. Speckle tracking–based strain echocardiography (STE) has been shown as a noninvasive, reproducible, and highly sensitive methodology to evaluate LV function in both animal models and humans. Herein, we describe the efficiency of this technique as a comprehensive and sensitive method for the detection of age-related cardiac dysfunction in mice. Compared with conventional echocardiographic measurements, radial and longitudinal strain, and reverse longitudinal strain were able to detect subtle changes in systolic and diastolic cardiac function in mice at an earlier time point during aging. Additionally, the data show a gradual and consistent decrease with age in regional contractility throughout the entire LV, in both radial and longitudinal axes. Furthermore, we observed that LV segmental dyssynchrony in longitudinal axis reliably differentiated between aged and young mice. Therefore, we propose the use of echocardiographic strain as a highly sensitive and accurate technology enabling and evaluating the effect of new treatments to fight age-induced cardiac disease.
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影响因子：
20.1
作者：
Duran JM;Makarewich CA;Sharp TE;Starosta T;Zhu F;Hoffman NE;Chiba Y;Madesh M;Berretta RM;Kubo H;Houser SR
通讯作者：
Houser SR
影响因子：
20.1
作者：
Bauer M;Cheng S;Jain M;Ngoy S;Theodoropoulos C;Trujillo A;Lin FC;Liao R
通讯作者：
Liao R
影响因子：
3.7
作者：
Bauer M;Metzler R
通讯作者：
Metzler R
影响因子：
5.7
作者：
Blessberger, Hermann;Binder, Thomas
通讯作者：
Binder, Thomas
影响因子：
37.8
作者：
Benjamin EJ;Blaha MJ;Chiuve SE;Cushman M;Das SR;Deo R;de Ferranti SD;Floyd J;Fornage M;Gillespie C;Isasi CR;Jiménez MC;Jordan LC;Judd SE;Lackland D;Lichtman JH;Lisabeth L;Liu S;Longenecker CT;Mackey RH;Matsushita K;Mozaffarian D;Mussolino ME;Nasir K;Neumar RW;Palaniappan L;Pandey DK;Thiagarajan RR;Reeves MJ;Ritchey M;Rodriguez CJ;Roth GA;Rosamond WD;Sasson C;Towfighi A;Tsao CW;Turner MB;Virani SS;Voeks JH;Willey JZ;Wilkins JT;Wu JH;Alger HM;Wong SS;Muntner P;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee