Urothelial progenitors in development and repair.
Urothelial progenitors in development and repair.
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DOI：
10.1007/s00467-021-05239-w
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发表时间：
2022-08
期刊：
影响因子：
--
通讯作者：
Becknell B
中科院分区：
文献类型：
--
作者：
Jackson AR;Narla ST;Bates CM;Becknell B
尿路上皮是一种特殊的多层上皮，排列在尿道近端至肾脏的尿路中。除了发育过程中的增殖和分化外，出生后的尿路上皮损伤触发了强大的再生能力，以恢复尿液和组织之间的保护屏障。越来越多的证据支持存在专门的祖细胞群，在发育过程中和对损伤的反应中产生尿路上皮。了解尿路上皮模式和修复的细胞和分子基础将为组织再生治疗提供信息，以改善尿路的许多结构和功能缺陷。在这里，我们回顾了目前对尿路上皮祖细胞和控制尿路上皮发育和修复的信号通路的理解。虽然大多数已发表的研究都集中在膀胱尿路上皮上，但我们也讨论了有关上尿路上皮祖细胞的文献。此外，我们还讨论了支持环境特异性祖细胞存在的证据。这些知识对于开发再生或改造受损或患病尿路上皮的策略至关重要。
Urothelium is a specialized multilayer epithelium that lines the urinary tract from the proximal urethra to the kidney. In addition to proliferation and differentiation during development, urothelial injury postnatally triggers a robust regenerative capacity to restore the protective barrier between the urine and tissue. Mounting evidence supports the existence of dedicated progenitor cell populations that give rise to urothelium during development and in response to injury. Understanding the cellular and molecular basis for urothelial patterning and repair will inform tissue regeneration therapies designed to ameliorate a number of structural and functional defects of the urinary tract. Here, we review the current understanding of urothelial progenitors and the signaling pathways that govern urothelial development and repair. While most published studies have focused on bladder urothelium, we also discuss literature on upper tract urothelial progenitors. Furthermore, we discuss evidence supporting existence of context-specific progenitors. This knowledge is fundamental to the development of strategies to regenerate or engineer damaged or diseased urothelium.
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