Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.
Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders.
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DOI：
10.1016/j.phrs.2011.04.007
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发表时间：
2011-09
影响因子：
9.3
通讯作者：
Mancuso, Cesare
中科院分区：
文献类型：
--
作者：
Butterfield, D. Allan;Barone, Eugenio;Mancuso, Cesare
他汀类药物长期以来一直被认为是通过降低血清胆固醇水平而发生血脂异常的情况下有益的，也被建议用于包括阿尔茨海默病在内的神经退行性疾病。然而，尚不清楚他汀类药物在神经退行性疾病中所谓的有效性是否与这些药物的降胆固醇作用直接相关；相反，他汀类药物的多效性功能可能起着关键作用。此外，随着更多研究的进行，他汀类药物在临床前研究中可能具有有害影响，在最近的各种临床试验中缺乏有效性，这一点变得越来越明显。这篇观点论文概述了他汀类药物在神经退行性疾病中使用的利弊，特别强调阿尔茨海默病。
Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed for use in neurodegenerative conditions, including Alzheimer disease. However, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. Moreover, it is becoming more apparent with additional studies that statins can have deleterious effects in preclinical studies and lack effectiveness in various recent clinical trials. This perspective paper outlines pros and cons of the use of statins in neurodegenerative disorders, with particular emphasis on Alzheimer disease.
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影响因子：
2.1
作者：
Horsdal, Henriette Thisted;Olesen, Anne Vingard;Johnsen, Soren Paaske
通讯作者：
Johnsen, Soren Paaske
影响因子：
37.8
作者：
Bellosta, S;Paoletti, R;Corsini, A
通讯作者：
Corsini, A
影响因子：
9.9
作者：
Cramer, C.;Haan, M. N.;Kalbfleisch, J. D.
通讯作者：
Kalbfleisch, J. D.
DOI：
10.1523/jneurosci.4144-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ghosh A;Roy A;Matras J;Brahmachari S;Gendelman HE;Pahan K
通讯作者：
Pahan K
影响因子：
11
作者：
Haag, M. D. M.;Hofman, A.;Breteler, M. M. B.
通讯作者：
Breteler, M. M. B.