αv integrins: key regulators of tissue fibrosis.
αv integrins: key regulators of tissue fibrosis.
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DOI：
10.1007/s00441-016-2407-9
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发表时间：
2016-09
影响因子：
3.6
通讯作者：
Henderson, Neil C.
中科院分区：
文献类型：
--
作者：
Conroy, Kylie P.;Kitto, Laura J.;Henderson, Neil C.
伴有纤维化的慢性组织损伤会导致组织结构破坏、器官功能障碍并最终导致器官衰竭。因此，迫切需要开发有效的抗纤维化疗法。在纤维发生过程中，伤口愈合反应的细胞和细胞外基质成分之间发生复杂的相互作用。整合素是跨膜细胞粘附分子家族，在介导细胞间和细胞-基质相互作用中发挥关键作用。因此，整联蛋白提供了细胞外基质、炎症细胞、成纤维细胞和实质细胞之间通讯的主要节点，因此，与组织纤维化的引发、维持和消退密切相关。 αv 整合素家族成员的调节对多个器官的纤维化和疾病状态表现出深远的影响。在这篇综述中，我们讨论了αv整合素介导的纤维发生调节机制的最新知识，并表明特定αv整合素的治疗靶向代表了治疗多种纤维化疾病患者的有希望的途径。
Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction and eventual organ failure. Therefore, the development of effective anti-fibrotic therapies is urgently required. During fibrogenesis, complex interplay occurs between cellular and extracellular matrix components of the wound healing response. Integrins, a family of transmembrane cell adhesion molecules, play a key role in mediating intercellular and cell-matrix interactions. Thus, integrins provide a major node of communication between the extracellular matrix, inflammatory cells, fibroblasts and parenchymal cells and, as such, are intimately involved in the initiation, maintenance and resolution of tissue fibrosis. Modulation of members of the αv integrin family has exhibited profound effects on fibrosis in multiple organs and disease states. In this review, we discuss the current knowledge of the mechanisms of αv-integrin-mediated regulation of fibrogenesis and show that the therapeutic targeting of specific αv integrins represents a promising avenue to treat patients with a broad range of fibrotic diseases.
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影响因子：
2.4
作者：
Iordanskaia, Tatiana;Hubal, Monica J.;Koeck, Emily;Rossi, Christopher;Schwarz, Kathleen;Nadler, Evan P.
通讯作者：
Nadler, Evan P.
影响因子：
82.9
作者：
通讯作者：
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影响因子：
3.2
作者：
BREUSS, JM;GILLETT, N;PYTELA, R
通讯作者：
PYTELA, R
DOI：
10.1097/mpg.0000000000000518
发表时间：
2014-12-01
影响因子：
2.9
作者：
Iordanskaia, Tatiana;Koeck, Emily;Nadler, Evan P.
通讯作者：
Nadler, Evan P.
DOI：
10.1164/rccm.200706-805oc
发表时间：
2008-01-01
影响因子：
24.7
作者：
Horan, Gerald S.;Wood, Susan;Violette, Shelia M.
通讯作者：
Violette, Shelia M.