Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress.
Left Ventricular Ejection Time Measured by Echocardiography Differentiates Neurobehavioral Resilience and Vulnerability to Sleep Loss and Stress.
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DOI：
10.3389/fphys.2021.795321
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发表时间：
2021
影响因子：
4
通讯作者：
Goel N
中科院分区：
文献类型：
--
作者：
Yamazaki EM;Rosendahl-Garcia KM;Casale CE;MacMullen LE;Ecker AJ;Kirkpatrick JN;Goel N
由于睡眠不足和心理压力，表现存在很大的个体差异（弹性和脆弱性），但预测潜在的生物标志物仍然难以捉摸。同样，睡眠不足和压力导致的心血管系统的显著变化包括心血管疾病风险的增加。目前尚不清楚关键的血流动力学指标，包括左心室射血时间（LVET），每搏输出量（SV），心率（HR），心脏指数（CI），血压（BP）和全身血管阻力指数（SVRI），是否在弹性与脆弱的个体之间存在差异，并预测不同的表现弹性与睡眠不足和压力。我们首次研究了完全睡眠剥夺（TSD）和心理压力的结合是否会影响健康成年人的一整套血流动力学指标，以及这些指标是否会区分弹性和脆弱个体的神经行为表现。32名健康成年人（年龄27-53岁; 14名女性）参加了为期5天的实验，在人类探索研究模拟（HERA），高保真美国国家航空航天局（NASA）的空间模拟隔离设施，包括两个基线夜，39小时TSD，和两个恢复夜。改良特里尔社会应激测试在TSD期间引起心理应激。分别在6个和11个时间点收集心血管指标[SV、HR、CI、LVET、BP和SVRI]和神经行为性能测试（包括行为注意力任务和主观嗜睡评级）。研究前LVET较长的个体（由研究前LVET的中位数分裂确定）在TSD和压力期间的表现往往较差。弹性和脆弱组（由平均TSD性能的中位数分割确定）显示出显著不同的SV、HR、CI和LVET特征。重要的是，研究前的LVET，而不是其他血流动力学指标，可靠地区分了TSD和应激期间的神经行为表现，因此可能是一种生物标志物。未来的研究应该调查非侵入性标志物LVET是否决定了不良健康结局的风险。
There are substantial individual differences (resilience and vulnerability) in performance resulting from sleep loss and psychosocial stress, but predictive potential biomarkers remain elusive. Similarly, marked changes in the cardiovascular system from sleep loss and stress include an increased risk for cardiovascular disease. It remains unknown whether key hemodynamic markers, including left ventricular ejection time (LVET), stroke volume (SV), heart rate (HR), cardiac index (CI), blood pressure (BP), and systemic vascular resistance index (SVRI), differ in resilient vs. vulnerable individuals and predict differential performance resilience with sleep loss and stress. We investigated for the first time whether the combination of total sleep deprivation (TSD) and psychological stress affected a comprehensive set of hemodynamic measures in healthy adults, and whether these measures differentiated neurobehavioral performance in resilient and vulnerable individuals. Thirty-two healthy adults (ages 27–53; 14 females) participated in a 5-day experiment in the Human Exploration Research Analog (HERA), a high-fidelity National Aeronautics and Space Administration (NASA) space analog isolation facility, consisting of two baseline nights, 39 h TSD, and two recovery nights. A modified Trier Social Stress Test induced psychological stress during TSD. Cardiovascular measure collection [SV, HR, CI, LVET, BP, and SVRI] and neurobehavioral performance testing (including a behavioral attention task and a rating of subjective sleepiness) occurred at six and 11 timepoints, respectively. Individuals with longer pre-study LVET (determined by a median split on pre-study LVET) tended to have poorer performance during TSD and stress. Resilient and vulnerable groups (determined by a median split on average TSD performance) showed significantly different profiles of SV, HR, CI, and LVET. Importantly, LVET at pre-study, but not other hemodynamic measures, reliably differentiated neurobehavioral performance during TSD and stress, and therefore may be a biomarker. Future studies should investigate whether the non-invasive marker, LVET, determines risk for adverse health outcomes.
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影响因子：
4.4
作者：
Akerstedt, Torbjorn;Anund, Anna;Kecklund, Goran
通讯作者：
Kecklund, Goran
影响因子：
3.6
作者：
Caldwell, J. Lynn;Schroeder, Valarie M.;Stephenson, Henry G.
通讯作者：
Stephenson, Henry G.
利用精神运动警觉性测试成绩的基线特征对注意力易受完全睡眠剥夺影响的程度进行分类
影响因子：
4.6
作者：
Chua, Eric Chern-Pin;Sullivan, Jason P.;Gooley, Joshua J.
通讯作者：
Gooley, Joshua J.
影响因子：
2.8
作者：
CUGINI, P;DIPALMA, L;LEONE, G
通讯作者：
LEONE, G
影响因子：
2.2
作者：
AKERSTEDT, T;GILLBERG, M
通讯作者：
GILLBERG, M