Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusion.
Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusion.
复制标题
DOI：
10.1002/mrm.21456
复制
发表时间：
2008-01
影响因子：
3.3
通讯作者：
Fox, Nick C.
中科院分区：
文献类型：
--
作者：
Tofts, Paul S.;Jackson, Jonathan S.;Tozer, Daniel J.;Cercignani, Mara;Keir, Geoffrey;MacManus, David G.;Ridgway, Gerard R.;Ridha, Basil H.;Schmierer, Klaus;Siddique, Durre;Thornton, John S.;Wroe, Stephen J.;Fox, Nick C.
有越来越多的兴趣在成像尸体的非侵入性尸检的研究目的。然而，温度远低于体内成像的温度，并观察到各种有趣的“冷脑”效应。在较低温度下，常规FLAIR序列不再产生暗脑脊液（CSF）; T1从体内约4.0秒减少到1°C时的1.7秒。CSF的扩散系数（DC）大大降低（从体内的3.1 × 10−9 m2 s −1降至1°C时的1.1）。因此，DC值提供了一种非侵入式温度计，可测量1.0°C以内的脑核心温度。在三具尸体中，DC值为1.1-1.5 × 10−9 m2 s −1，表明大脑核心温度为1-10°C，与外部热电偶测量结果一致。然后可以发现FLAIR的改进的反转时间（TI 0）。在10°C下，该冷FLAIR序列（TI 0 = 1.5秒）得到黑色CSF。产生作为温度的函数的CSF DC和T1的表达。CSFDC的测量值可直接转换为温度，并找到所需的TI 0，CSFDC的体外值比水低约1%。因此，FLAIR成像可以在低温和未知温度下针对尸体大脑进行优化，从而提高尸检目的的价值，并便于与体内成像进行比较。
There is increasing interest in imaging cadavers for noninvasive autopsies for research purposes. However, the temperature is well below that of in vivo imaging, and a variety of interesting ‘cold brain’ effects are observed. At lower temperatures conventional FLAIR sequences no longer produce dark cerebrospinal fluid (CSF); T1 is reduced from about 4.0 sec in vivo to 1.7 sec at 1°C. The diffusion coefficient (DC) of CSF is much reduced (from 3.1 10−9 m2s−1 in vivo to 1.1 at 1°C). DC values therefore provide a noninvasive thermometer to measure brain core temperature to within 1.0°C. In three cadavers DC values were 1.1-1.5 10−9 m2s−1, indicating brain core temperatures of 1-10°C, consistent with external thermocouple measurements. An improved inversion time (TI0) can then be found for FLAIR. At 10°C this Cold FLAIR sequence (TI0 = 1.5 sec) gave black CSF. Expressions for CSF DC and T1 as a function of temperature were produced. A measurement of CSF DC could be converted directly to temperature and the required TI0 found. In vitro values of CSF DC were about 1% lower than that of water. Thus, FLAIR imaging can be optimized for cadaveric brains at low and unknown temperatures, thereby improving value for autopsy purposes and facilitating comparisons with in vivo imaging.
登录
查看更多内容
DOI：
10.1002/0470869526.ch3
发表时间：
2003-01-01
期刊：
QUANTITATIVE MRI OF THE BRAIN: MEASURING CHANGES CAUSED BY DISEASE
影响因子：
--
作者：
Tofts, Paul S.
通讯作者：
Tofts, Paul S.
影响因子：
3.3
作者：
Hakyemez, B;Aksoy, U;Ergin, N
通讯作者：
Ergin, N
影响因子：
3.3
作者：
Zaharchuk, G;Martin, AJ;Dillon, WP
通讯作者：
Dillon, WP
影响因子：
1.3
作者：
HAJNAL, JV;BRYANT, DJ;BYDDER, GM
通讯作者：
BYDDER, GM
影响因子：
--
作者：
KRYNICKI, K
通讯作者：
KRYNICKI, K