RIG-I is cleaved during picornavirus infection.
RIG-I is cleaved during picornavirus infection.
复制标题
DOI：
10.1016/j.virol.2009.06.045
复制
发表时间：
2009-09-01
期刊：
影响因子：
3.7
通讯作者：
Racaniello, Vincent R.
中科院分区：
文献类型：
--
作者：
Barral, Paola M.;Sarkar, Devanand;Fisher, Paul B.;Racaniello, Vincent R.
The innate immune system senses RNA virus infections through membrane-bound Toll-like receptors or the cytoplasmic proteins RIG-I and MDA-5. RIG-I is believed to recognize the 5′-triphosphate present on many viral RNAs, and hence is important for sensing infections by paramyxoviruses, influenza viruses, rhabdoviruses, and flaviviruses. MDA-5 recognizes dsRNA, and senses infection with picornaviruses, whose RNA 5′-ends are linked to a viral protein, VPg, not a 5′-triphosphate. We previously showed that MDA-5 is degraded in cells infected with different picornaviruses, and suggested that such cleavage might be a mechanism to antagonize production of type I IFN in response to viral infection. Here we examined the state of RIG-I during picornavirus infection. RIG-I is degraded in cells infected with poliovirus, rhinoviruses, echovirus, and encephalomyocarditis virus. In contrast to MDA-5, cleavage of RIG-I is not accomplished by cellular caspases or the proteasome. Rather, the viral proteinase 3Cpro cleaves RIG-I, both in vitro and in cells. Cleavage of RIG-I during picornavirus infection may constitute another mechanism for attenuating the innate response to viral infection.
登录
查看更多内容
影响因子：
56.9
作者：
Pichlmair, Andreas;Schulz, Oliver;Sousa, Caetano Reis E.
通讯作者：
Sousa, Caetano Reis E.
影响因子：
64.8
作者：
Meylan, E;Curran, J;Tschopp, R
通讯作者：
Tschopp, R
影响因子：
30.5
作者：
Kawai, T;Takahashi, K;Akira, S
通讯作者：
Akira, S
影响因子：
64.8
作者：
Saito, Takeshi;Owen, David M.;Gale, Michael, Jr.
通讯作者：
Gale, Michael, Jr.
影响因子：
5
作者：
Weidman, MK;Sharma, R;Dasgupta, A
通讯作者：
Dasgupta, A