Intrathecal IgG synthesis and specificity of oligoclonal IgG in patients infected with HIV‐1 do not correlate with CNS disease
Intrathecal IgG synthesis and specificity of oligoclonal IgG in patients infected with HIV‐1 do not correlate with CNS disease
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HIV-1 感染患者鞘内 IgG 合成和寡克隆 IgG 特异性与 CNS 疾病无关
DOI：
--
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发表时间：
1991
影响因子：
12.7
通讯作者：
R. Tedder
中科院分区：
文献类型：
--
作者：
K. Goswami;S. Kaye;Robert F. Miller;R. McAllister;R. Tedder
The CSF/serum immune response to HIV 1 was studied in 24 patients admitted for investigation. The level of antibody to HIV‐1 and specificity of oligoclonal IgG were determined in blood and cerebrospinal fluid (CSF). The majority of patients demonstrated elevated levels of intrathecal IgG synthesis, with levels of HIV‐l‐specific antibody frequently being significantly higher in CSF than in serum. In 16 of 21 patients the CSF/serum antibody ratio indicated active intrathecal synthesis. Oligoclonal banding was present in CSF from all 24 patients. lmmunoprinting of serum and CSF demonstrated antigenic specificity (p24, gp 160, RT) of the clonal antibodies in all of 12 patients though the patterns of reactivity in CSF did not necessarily correspond with that of serum. Although a specific association of particular patterns with HIV CNS disease was not found we feel that these markers should be included in longitudinal studies of HIV‐related diseases of the CNS. The specificity of oligoclonal antibodies, both in CSF and in serum was demonstrated, and this specificity may be a useful marker for longitudinal studies in HIV‐1 antibody‐positive asymptomatic patients.
DOI：
10.1073/pnas.83.18.7089
发表时间：
1986-09-01
影响因子：
11.1
作者：
WILEY, CA;SCHRIER, RD;OLDSTONE, MBA
通讯作者：
OLDSTONE, MBA