Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.
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DOI：
10.1007/s00702-017-1713-z
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Kimura M
中科院分区：
文献类型：
--
作者：
Yamanaka K;Hori Y;Minamimoto T;Yamada H;Matsumoto N;Enomoto K;Aosaki T;Graybiel AM;Kimura M
丘脑向纹状体提供大量输入，但尽管证据越来越多，该系统的功能仍不清楚。然而，众所周知，丘脑的中位核（CM）和束旁核（Pf）可以强烈影响特定的纹状体神经元亚型，特别是纹状体的胆碱能中间神经元（CINs），纹状体功能的关键调节因子。这里我们通过CM-Pf到纹状体CINs来强调丘脑纹状体系统。我们考虑通过CM和Pf的直接突触连接，它们的神经活动如何促进CINs和纹状体投射神经元（spn）的活动。CM-Pf神经元在行为环境的突然变化时被强烈激活，如动作-结果偶然性或行为要求序列的切换，这表明它们的活动可能代表了被联想性操作的环境变化。另一方面，纹状体CINs对与特定环境相关的外部事件获得和放松反应。根据这一生理证据，我们提出了CM-Pf - CINs系统的假设，认为它通过产生联想性信号来增强联想学习，并通过来自含多巴胺神经元的奖励预测误差信号来促进强化学习。我们讨论基于体内/体外研究的神经元回路和突触组织，我们认为这是我们假设的基础。CM-Pf - CINs功能障碍（或变性）在脑部疾病中的可能影响也被重点讨论帕金森病。
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) nuclei of the thalamus can strongly influence particular striatal neuron subtypes, notably including the cholinergic interneurons of the striatum (CINs), key regulators of striatal function. Here we highlight the thalamostriatal system through the CM-Pf to striatal CINs. We consider how, by virtue of the direct synaptic connections of the CM and Pf, their neural activity contributes to the activity of CINs and striatal projection neurons (SPNs). CM-Pf neurons are strongly activated at sudden changes in behavioral context, such as switches in action-outcome contingency or sequence of behavioral requirements, suggesting that their activity may represent change of context operationalized as associability. Striatal CINs, on the other hand, acquire and loose responses to external events associated with particular contexts. In light of this physiological evidence, we propose a hypothesis of the CM-Pf - CINs system, suggesting that it augments associative learning by generating an associability signal and promotes reinforcement learning guided by reward prediction error signals from dopamine-containing neurons. We discuss neuronal circuit and synaptic organizations based on in vivo/in vitro studies that we suppose to underlie our hypothesis. Possible implications of CM-Pf - CINs dysfunction (or degeneration) in brain diseases are also discussed by focusing on Parkinson’s disease.
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影响因子：
2.9
作者：
Crittenden JR;Graybiel AM
通讯作者：
Graybiel AM
影响因子：
25
作者：
Ding, Jun;Guzman, Jaime N.;Surmeier, D. James
通讯作者：
Surmeier, D. James
DOI：
10.1073/pnas.1014457108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Enomoto, Kazuki;Matsumoto, Naoyuki;Kimura, Minoru
通讯作者：
Kimura, Minoru
影响因子：
7.8
作者：
Butts, DA
通讯作者：
Butts, DA
影响因子：
2.5
作者：
AOSAKI, T;KIMURA, M;GRAYBIEL, AM
通讯作者：
GRAYBIEL, AM