Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments.
Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments.
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DOI：
10.3389/fnana.2011.00059
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发表时间：
2011
影响因子：
2.9
通讯作者：
Graybiel AM
中科院分区：
文献类型：
--
作者：
Crittenden JR;Graybiel AM
纹状体主要由GABA能，中刺纹状体投影神经元（MSN）组成，可以根据其基因表达，电生理谱和输入输入 - 输入 - 输入电路进行分类。 （2）引起直接和间接途径的区域，以及（3）位于前两个室中的途径然而，尽管有大量的分子在链球菌或特级矩阵中表达了大量的分子，但经典方案使基本的神经节回路如何促进疾病。 ，我们对这种隔室化如何促进纹状体功能的理解仍然不清楚。构成感觉运动和联想电路部分的MSN，而细息膜包含从边缘皮层的部分接收输入的MSN，并直接或间接地向含有多巴胺的Nigra nigra nigra compacta和PARS Compacta中均具有良好的含量。被认为是通过与周围矩阵的交换信息来对纹状体处理的影响以及本地的影响，包括通过发送流程的中间神经元在两个隔室中，都建议静脉曲张施加并保持对周围的感觉运动驱动的行为和纹状体矩阵的关联部位的行为。亨廷顿氏病，L-DOPA引起的运动障碍，肌张力障碍和吸毒成瘾。在静脉曲张和基质之间可能与这些疾病中的症状学有关。
The striatum is composed principally of GABAergic, medium spiny striatal projection neurons (MSNs) that can be categorized based on their gene expression, electrophysiological profiles, and input–output circuits. Major subdivisions of MSN populations include (1) those in ventromedial and dorsolateral striatal regions, (2) those giving rise to the direct and indirect pathways, and (3) those that lie in the striosome and matrix compartments. The first two classificatory schemes have enabled advances in understanding of how basal ganglia circuits contribute to disease. However, despite the large number of molecules that are differentially expressed in the striosomes or the extra-striosomal matrix, and the evidence that these compartments have different input–output connections, our understanding of how this compartmentalization contributes to striatal function is still not clear. A broad view is that the matrix contains the direct and indirect pathway MSNs that form parts of sensorimotor and associative circuits, whereas striosomes contain MSNs that receive input from parts of limbic cortex and project directly or indirectly to the dopamine-containing neurons of the substantia nigra, pars compacta. Striosomes are widely distributed within the striatum and are thought to exert global, as well as local, influences on striatal processing by exchanging information with the surrounding matrix, including through interneurons that send processes into both compartments. It has been suggested that striosomes exert and maintain limbic control over behaviors driven by surrounding sensorimotor and associative parts of the striatal matrix. Consistent with this possibility, imbalances between striosome and matrix functions have been reported in relation to neurological disorders, including Huntington’s disease, L-DOPA-induced dyskinesias, dystonia, and drug addiction. Here, we consider how signaling imbalances between the striosomes and matrix might relate to symptomatology in these disorders.
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影响因子：
3.3
作者：
BESSON, MJ;GRAYBIEL, AM;NASTUK, MA
通讯作者：
NASTUK, MA
影响因子：
2.7
作者：
Badiani, A;Oates, MM;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
DOI：
10.1124/jpet.112.192138
发表时间：
2012-09-01
影响因子：
3.5
作者：
Johri, Ashu;Beal, M. Flint
通讯作者：
Beal, M. Flint
DOI：
10.1073/pnas.1009874107
发表时间：
2010-08-17
影响因子：
11.1
作者：
Bateup, Helen S.;Santini, Emanuela;Greengard, Paul
通讯作者：
Greengard, Paul