The correlation between IL-20 and the Th2 immune response in human asthma.
The correlation between IL-20 and the Th2 immune response in human asthma.
复制标题
IL-20 与人类哮喘中 Th2 免疫反应之间的相关性。
DOI：
10.12932/ap0447.32.4.2014
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Dong, Liang
中科院分区：
文献类型：
--
作者：
Wang, Guicheng;Hao, Junqing;Gong, Wenbin;Dong, Liang
BACKROUND
BACKROUND
Interleukin-20 (IL-20) belongs to the IL-10 family, which has been shown to be crucial in immune responses, regulation of inflammatory responses, hemopoiesis, and epidermal cell and keratinocyte differentiation. However, the role of IL-20 in asthma remains unclear. Here, our aim is to evaluate the correlation between IL-20 and the Th2 immune response in human.
METHODS
In this study, we recruited 100 asthma patients and 100 control subjects for collection of serum samples and biopsy material. Firstly, We observed the expression of IL-20 in the airway epithelium of asthma patients by immuno-histochemical analysis, and then used an enzyme-linked immune-sorbent assay (ELISA) to analyze the serum levels of IL-20, IL-4, IL-5 and IL-13 in patients with asthma.
RESULTS
We found high levels of expression of IL-20 in the airway epithelium of asthma patients. We also found that the concentrations of IL-20 and the Th2 cytokines, IL-4, IL-5 and IL-13, were significantly higher in patients with asthma and a positive correlation were found between IL-20 and Th2 cytokines (IL-4, IL-5, and IL-13). Furthermore, levels of IL-20 gradually increased according to the severity of the asthma.
CONCLUSIONS
IL-20 levels are increased in the epithelium and serum of asthmatic patients. The correlation between IL-20 levels and Th2 cytokines suggests that IL-20 may play a patho-physiologic role in the Th2 immune response in human asthma and may be a potential biomarker of asthma severity.
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影响因子：
16.8
作者：
H. Volk;K. Asadullah;G. Gallagher;R. Sabat;G. Grutz
通讯作者：
H. Volk;K. Asadullah;G. Gallagher;R. Sabat;G. Grutz
影响因子：
1.5
作者：
Williams, Cara M. M.;Rahman, Saifur;Ma, Hak-Ling
通讯作者：
Ma, Hak-Ling
DOI：
10.1084/jem.20050199
发表时间：
2005-09-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Al-Shami A;Spolski R;Kelly J;Keane-Myers A;Leonard WJ
通讯作者：
Leonard WJ
影响因子：
3.6
作者：
Wu, Jinxiang;Liu, Fen;Tian, Hong
通讯作者：
Tian, Hong
DOI：
10.4049/jimmunol.181.11.8170
发表时间：
2008-12
期刊：
The Journal of Immunology
影响因子：
--
作者：
M. Kurowska-Stolarska;P. Kewin;G. Murphy;R. C. Russo;B. Stolarski;Cristiana Couto Garcia;M. Komai‐Koma;N. Pitman;Yubin Li;W. Niedbala;Andrew N. J. McKenzie;Mauro M Teixeira;Fooyew Liew;Damo Xu
通讯作者：
M. Kurowska-Stolarska;P. Kewin;G. Murphy;R. C. Russo;B. Stolarski;Cristiana Couto Garcia;M. Komai‐Koma;N. Pitman;Yubin Li;W. Niedbala;Andrew N. J. McKenzie;Mauro M Teixeira;Fooyew Liew;Damo Xu