Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system.
Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system.
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DOI：
10.1038/s41598-018-24195-4
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发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
Lyu P
中科院分区：
文献类型：
--
作者：
Dong F;Tao C;Wu J;Su Y;Wang Y;Wang Y;Guo C;Lyu P
本研究旨在评估非辐射、非侵入性红外热成像系统对口腔癌颈部淋巴结转移的诊断价值。在这项前瞻性临床试验中，共90例怀疑有颈部淋巴结转移的口腔癌患者在颈部清扫前接受了颈部红外成像。采用人工定性分析和熵梯度支持向量机（EGSVM）自动分析两种方法对红外图像进行分析。采用非劣效性检验方法对基于egsvm的红外热成像系统与CT的成像效果进行了比较。与人工定性分析相比，基于egsvm的自动分析灵敏度（84.8% vs. 71.7%）、特异性（77.3% vs. 72.7%）、准确性（81.1% vs. 72.2%）、阳性预测值（79.6% vs. 73.3%）和阴性预测值（82.9% vs. 71.1%）更高。基于egsvm的红外热成像系统不逊于对比增强CT （P < 0.05）。基于egsvm的红外热成像系统表现出灵敏度更高的趋势，而对比增强CT表现出特异性更高的趋势。基于egsvm的红外热成像系统是一种很有前途的无辐射、无创检测口腔癌淋巴结转移的工具。
This study aimed to evaluate the diagnostic performance of a non-radiating, noninvasive infrared (IR) thermal imaging system in the detection of cervical lymph node metastasis from oral cavity cancer. In this prospective clinical trial, a total of 90 oral cavity cancer patients suspected of having cervical lymph node metastasis underwent IR imaging of the neck prior to neck dissection. Analysis of the IR images was performed by two methods: manual qualitative analysis and automatic analysis by an entropy-gradient support vector machine (EGSVM). The efficacies of the EGSVM-based infrared thermal imaging system and contrast-enhanced computed tomography (CT) were compared by using the Noninferiority Testing. Compared with manual qualitative analysis, the EGSVM-based automatic analysis had a higher sensitivity (84.8% vs. 71.7%), specificity (77.3% vs. 72.7%), accuracy (81.1% vs. 72.2%), positive predictive value (79.6% vs. 73.3%) and negative predictive value (82.9% vs. 71.1%). The EGSVM-based infrared thermal imaging system was noninferior to contrast-enhanced CT (P < 0.05). The EGSVM-based infrared thermal imaging system showed a trend of higher sensitivity, whereas contrast-enhanced CT showed a trend of higher specificity. The EGSVM-based infrared thermal imaging system is a promising non-radiating, noninvasive tool for the detection of lymph node metastasis from oral cavity cancer.
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DOI：
10.1016/j.ijthermalsci.2010.10.019
发表时间：
2011-04-01
影响因子：
4.5
作者：
Cetinguel, M. Pirtini;Herman, C.
通讯作者：
Herman, C.
DOI：
10.1109/pgec.1965.264137
发表时间：
1965-01-01
期刊：
IEEE TRANSACTIONS ON ELECTRONIC COMPUTERS
影响因子：
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254.7
作者：
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Pisani, P
影响因子：
10.3
作者：
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通讯作者：
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影响因子：
10.6
作者：
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