A hitchhiker's guide to cancer models.
A hitchhiker's guide to cancer models.
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DOI:
10.1016/j.tibtech.2022.04.003
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发表时间:
2022-11
影响因子:
17.3
通讯作者:
Charania, Areesha A.
中科院分区:
文献类型:
--
作者:
Budhwani, Karim I.;Patel, Zeelu H.;Guenter, Rachael E.;Charania, Areesha A.
Cancer is a complex and uniquely personal disease. More than 1.7 million people in the United States are diagnosed with cancer every year. As the burden of cancer grows, so does the need for new, more effective therapeutics and for predictive tools to identify optimal, personalized treatment options for every patient. Cancer models that recapitulate various aspects of the disease are fundamental to making advances along the continuum of cancer treatment from bench-side discoveries to bed-side delivery. In this review, we use a thought experiment as a vehicle to arrive at four broad categories of cancer models and explore the strengths, weaknesses, opportunities, and threats (SWOT) for each category in advancing our understanding of the disease and improving treatment strategies.
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DOI:
10.1038/nrd4539
发表时间:
2015-04
期刊:
Nature reviews. Drug discovery
影响因子:
--
作者:
Esch EW;Bahinski A;Huh D
通讯作者:
Huh D
影响因子:
5.2
作者:
Betzler AM;Nanduri LK;Hissa B;Blickensdörfer L;Muders MH;Roy J;Jesinghaus M;Steiger K;Weichert W;Kloor M;Klink B;Schroeder M;Mazzone M;Weitz J;Reissfelder C;Rahbari NN;Schölch S
通讯作者:
Schölch S
影响因子:
64.8
作者:
通讯作者:
--
影响因子:
6.1
作者:
Aref AR;Campisi M;Ivanova E;Portell A;Larios D;Piel BP;Mathur N;Zhou C;Coakley RV;Bartels A;Bowden M;Herbert Z;Hill S;Gilhooley S;Carter J;Cañadas I;Thai TC;Kitajima S;Chiono V;Paweletz CP;Barbie DA;Kamm RD;Jenkins RW
通讯作者:
Jenkins RW
影响因子:
3.8
作者:
Herring B;Whitt J;Aweda T;Ou J;Guenter R;Lapi S;Berry J;Chen H;Liu X;Rose JB;Jaskula-Sztul R
通讯作者:
Jaskula-Sztul R