A hitchhiker's guide to cancer models.

A hitchhiker's guide to cancer models.
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DOI:
10.1016/j.tibtech.2022.04.003
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发表时间:
2022-11
影响因子:
17.3
通讯作者:
Charania, Areesha A.
Charania, Areesha A.
中科院分区:
工程技术1区
文献类型:
--
作者:
Budhwani, Karim I.;Patel, Zeelu H.;Guenter, Rachael E.;Charania, Areesha A.

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Cancer is a complex and uniquely personal disease. More than 1.7 million people in the United States are diagnosed with cancer every year. As the burden of cancer grows, so does the need for new, more effective therapeutics and for predictive tools to identify optimal, personalized treatment options for every patient. Cancer models that recapitulate various aspects of the disease are fundamental to making advances along the continuum of cancer treatment from bench-side discoveries to bed-side delivery. In this review, we use a thought experiment as a vehicle to arrive at four broad categories of cancer models and explore the strengths, weaknesses, opportunities, and threats (SWOT) for each category in advancing our understanding of the disease and improving treatment strategies.
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