Ocular torsion responses to sinusoidal electrical vestibular stimulation.
Ocular torsion responses to sinusoidal electrical vestibular stimulation.
复制标题
眼扭转对正弦电的前庭刺激的反应。
DOI：
10.1016/j.jneumeth.2017.11.012
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发表时间：
2018-01-15
影响因子：
3
通讯作者：
Reynolds RF
中科院分区：
文献类型：
--
作者：
Mackenzie SW;Reynolds RF
我们测量了对正弦电前庭刺激的眼部扭转反应。在 0.05 至 20 Hz 的所有频率下观察到响应。增益和相位分析表明，中枢神经系统将刺激解释为速度。我们的非侵入性方法以自然刺激不可能达到的频率评估扭转 VOR。前庭电刺激（EVS）引起的眼球运动为诊断前庭功能障碍提供了潜力。然而，眼部记录技术对于常规临床使用来说通常侵入性太大或不切实际。此外，EVS 信号的运动学性质在运动感觉方面尚未完全理解。我们应用 0.05 至 20 Hz 的正弦 EVS 刺激，并使用红外摄像机在黑暗中记录眼睛。使用市售软件跟踪虹膜条纹来离线测量眼球运动。分别计算所有频率下眼睛位置、速度和加速度的响应增益和相位，以确定大脑如何解释 EVS 信号。对于所有频率，在与刺激相同的频率下观察到眼部扭转反应，而横向/垂直反应最小或不存在。响应增益和相位类似于之前报道的对自然旋转的响应，但仅在分析眼睛速度时，而不是在分析位置或加速度时。我们的方法提供了一种简单、经济、可靠且非侵入性的方法来跟踪 EVS 的眼部反应。它比巩膜线圈记录或标记巩膜以帮助视频跟踪更方便。它还使我们能够评估自然刺激不可能实现的频率下的扭转 VOR。使用正弦刺激与红外相机相结合，可以轻松评估 EVS 的眼部扭转反应。增益和相位分析表明中枢神经系统将刺激解释为头部滚动速度。未来的工作将评估前庭疾病患者的诊断潜力。
We measured ocular torsion responses to sinusoidal Electrical Vestibular Stimulation. Responses were observed at all frequencies from 0.05 to 20 Hz. Gain and phase analysis suggest the stimulus is interpreted by the CNS as velocity. Our non-invasive method assesses torsional VOR at frequencies impossible with natural stimuli. Eye movements evoked by electrical vestibular stimulation (EVS) offer potential for diagnosing vestibular dysfunction. However, ocular recording techniques are often too invasive or impractical for routine clinical use. Furthermore, the kinematic nature of the EVS signal is not fully understood in terms of movement sensations. We apply sinusoidal EVS stimuli varying from 0.05 to 20 Hz, and record the eye in darkness using an infrared camera. Eye movement was measured offline using commercially available software to track iris striations. Response gain and phase were calculated separately for eye position, velocity and acceleration across all frequencies, to determine how the brain interprets the EVS signal. Ocular torsion responses were observed at the same frequency as the stimulus, for all frequencies, while lateral/vertical responses were minimal or absent. Response gain and phase resembled previously reported responses to natural rotation, but only when analysing eye velocity, not position or acceleration. Our method offers a simple, affordable, reliable and non-invasive method for tracking the ocular response to EVS. It is more convenient than scleral coil recordings, or marking the sclera to aid video tracking. It also allows us to assess the torsional VOR at frequencies not possible with natural stimuli. Ocular torsion responses to EVS can be readily assessed using sinusoidal stimuli combined with an infrared camera. Gain and phase analysis suggests that the central nervous system interprets the stimulus as head roll velocity. Future work will assess the diagnostic potential for patients with vestibular disorders.
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影响因子：
3.7
作者：
Aw ST;Todd MJ;Lehnen N;Aw GE;Weber KP;Eggert T;Halmagyi GM
通讯作者：
Halmagyi GM
影响因子：
2
作者：
Cauquil, AS;Faldon, M;Bronstein, AM
通讯作者：
Bronstein, AM
影响因子：
1.7
作者：
Schneider, E;Glasauer, S;Dieterich, M
通讯作者：
Dieterich, M
DOI：
10.1016/s0013-4694(98)00056-x
发表时间：
1998-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Zink, R;Bucher, SF;Dieterich, M
通讯作者：
Dieterich, M
影响因子：
2.1
作者：
MacDougall, HG;Brizuela, AE;Halmagyi, GM
通讯作者：
Halmagyi, GM