Prevalence and risk factors associated with asymptomatic Plasmodium falciparum infection and anemia among pregnant women at the first antenatal care visit: A hospital based cross-sectional study in Kwale County, Kenya.
Prevalence and risk factors associated with asymptomatic Plasmodium falciparum infection and anemia among pregnant women at the first antenatal care visit: A hospital based cross-sectional study in Kwale County, Kenya.
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DOI：
10.1371/journal.pone.0239578
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Jeza VT
中科院分区：
文献类型：
--
作者：
Nyamu GW;Kihara JH;Oyugi EO;Omballa V;El-Busaidy H;Jeza VT
肯尼亚孕期疟疾流行率从9%到18%不等。我们评估了参加产前护理(ANC)的无症状妇女中MIP和妊娠期贫血(AIP)的患病率和相关因素。我们在2018年9月至2019年2月期间对在Msambweni医院接受ANC治疗的孕妇进行了一项横断面研究。在Epi Info 7中收集和分析数据，计算描述性统计，并将无症状病例与无症状病例的MiP和AIP进行比较。计算调整后的患病率优势比(APOR)和95%可信区间(CI)，以确定与无症状MIP和AIP相关的因素。我们访问了308名研究参与者，他们的平均年龄为26.6岁(±5.8岁)，平均孕周为21.8周(±6.0周)，173名(56.2%)在孕中期，12.9%(40/308)患有MIP，62.7%患有AIP。年龄20岁的≤患者发生MIP的可能性是20岁患者的3倍(APOR=3.1CI：1.3-7.35)。胎龄≥为16周(APOR=3.9，CI：1.96~7.75)、有寄生虫血症(APOR=3.3，95%CI：1.3 1~8.18)、妊娠晚期(APOR=2.6，95%CI：1.4 0~4.96)、孕期有贪食土壤者(APOR=1.9，95%CI：1.15~3.2 9)发生早孕的可能性较高。大多数女性有无症状的MIP和AIP。所有研究参与者中有十分之一的人观察到了MIP。无症状的MIP与年龄较小有关，而AIP与胎龄、寄生虫血症和孕期对土壤的渴求有关。
Prevalence of Prevalence of malaria in pregnancy (MiP) in Kenya ranges from 9% to 18%. We estimated the prevalence and factors associated with MiP and anemia in pregnancy (AiP) among asymptomatic women attending antenatal care (ANC) visits. We performed a cross-sectional study among pregnant women attending ANC at Msambweni Hospital, between September 2018 and February 2019. Data was collected and analyzed in Epi Info 7. Descriptive statistics were calculated and we compared MiP and AiP in asymptomatic cases to those without either condition. Adjusted prevalence Odds odds ratios (aPOR) and 95% confidence intervals (CI) were calculated to identify factors associated with asymptomatic MiP and AiP. We interviewed 308 study participants; their mean age was 26.6 years (± 5.8 years), mean gestational age was 21.8 weeks (± 6.0 weeks), 173 (56.2%) were in the second trimester of pregnancy, 12.9% (40/308) had MiP and 62.7% had AiP. Women who were aged ≤ 20 years had three times likelihood of developing MiP (aPOR = 3.1 Cl: 1.3–7.35) compared to those aged >20 years old. The likelihood of AiP was higher among women with gestational age ≥ 16 weeks (aPOR = 3.9, CI: 1.96–7.75), those with parasitemia (aPOR = 3.3, 95% CI: 1.31–8.18), those in third trimester of pregnancy (aPOR = 2.6, 95% CI:1.40–4.96) and those who reported eating soil as a craving during pregnancy (aPOR = 1.9, 95%CI:1.15–3.29). Majority of the women had asymptomatic MiP and AiP. MiP was observed in one tenth of all study participants. Asymptomatic MiP was associated with younger age while AiP was associated with gestational age parasitemia, and soil consumption as a craving during pregnancy.
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