Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines
Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines
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响应多种细胞因子，快速激活与干扰素γ激活位点相互作用的蛋白质
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
J. Rosen
中科院分区：
文献类型：
--
作者：
P. Lamb;L. Kessler;C. Suto;D. Levy;H. Seidel;R. Stein;J. Rosen
Many cytokines and growth factors trigger rapid changes in gene expression upon binding to their receptors. In many cases, the mechanism by which these changes are affected is unknown. In this report, we show that interleukin-2 (IL-2), IL-3, IL-4, IL-6, leukemia inhibitory factor (LIF), erythropoietin (Epo), and granulocyte- macrophage colony-stimulating factor (GM-CSF) treatment of cells causes rapid activation of DNA-binding activities that recognize a DNA sequence element previously implicated in regulation of gene expression by interferon gamma (IFN gamma). The IL-4-, IL-6-, and GM-CSF-induced complexes can be distinguished from the recently characterized IFN gamma-activated protein p91 on the basis of mobility in polyacrylamide gels, sequence preferences, and lack of reactivity with an anti-p91 antiserum. The IL-4- and GM-CSF-induced complexes react with antiphosphotyrosine antibodies, demonstrating the presence of phosphotyrosine-containing proteins in these DNA-binding complexes. Transcriptional activation of a reporter gene linked to a synthetic IFN gamma-responsive promoter is observed in response to IFN gamma, IL-6, and LIF. These data suggest a pathway by which cytokines induce rapid changes in gene expression.
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DOI：
10.1073/pnas.87.21.8555
发表时间：
1990-11-01
影响因子：
11.1
作者：
FU, XY;KESSLER, DS;DARNELL, JE
通讯作者：
DARNELL, JE
影响因子：
10.5
作者：
KESSLER, DS;VEALS, SA;LEVY, DE
通讯作者：
LEVY, DE
通过转录因子酪氨酸磷酸化实现不依赖于 Ras 的生长因子信号传导。
DOI：
10.1126/science.8378775
发表时间：
1993
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Silvennoinen,O;Schindler,C;Schlessinger,J;Levy,DE
通讯作者：
Levy,DE
影响因子：
56.9
作者：
SCHINDLER, C;SHUAI, K;DARNELL, JE
通讯作者：
DARNELL, JE
白细胞介素 3、粒细胞巨噬细胞集落刺激因子和转染的促红细胞生成素受体介导 FDC-ER 细胞中常见胞浆蛋白 (pp100) 的酪氨酸磷酸化。
DOI：
--
发表时间：
1992
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Quelle,FW;Quelle,DE;Wojchowski,DM
通讯作者：
Wojchowski,DM