Evaluation of a new polyvalent Pseudomonas vaccine in respiratory infections
Evaluation of a new polyvalent Pseudomonas vaccine in respiratory infections
复制标题
新型多价假单胞菌疫苗治疗呼吸道感染的评价
作者：
J. Pennington;J. Miler
使用实验性假单胞菌肺炎豚鼠模型对一种新的多价细胞壁提取物铜绿假单胞菌疫苗 (PEV-01) 进行了评估。在两周内注射四次疫苗后，豚鼠的血清血凝假单胞菌抗体通常会增加四倍。接种疫苗的动物在气管内假单胞菌攻击中的存活率（1 X 10(8) 菌落形成单位）明显优于对照组（14 只中的 13 只存活）（14 只中的 5 只存活）（P 小于 0.01）。感染后 3 小时（P 小于 0.02）和 6 小时（P 小于 0.05）时，接种者肺组织中活假单胞菌的清除率明显优于对照组。肺组织的肉眼检查和组织学检查均显示，接种疫苗的动物在感染假单胞菌后肺组织损伤较少。因此，PEV-01 假单胞菌疫苗似乎能够在豚鼠呼吸道中引发特异性保护反应。
A new polyvalent, cell wall extract, Pseudomonas aeruginosa vaccine (PEV-01), was evaluated by using a guinea pig model of experimental Pseudomonas pneumonia. Guinea pigs routinely developed fourfold rises in serum hemagglutinating Pseudomonas antibodies after four vaccine injections given over 2 weeks. Vaccinated animals survived an intratracheal Pseudomonas challenge (1 X 10(8) colony-forming units) significantly better (13 of 14 survived) than did a control group (5 of 14 survived) (P less than 0.01). Clearance of viable Pseudomonas from lung tissue was significantly better in vaccinees than controls at both 3 h (P less than 0.02) and 6 h (P less than 0.05) after infection. Both gross and histological examinations of lung tissue revealed less pulmonary tissue damage in vaccinated animals following Pseudomonas infection. Thus, PEV-01 Pseudomonas vaccine appears capable of eliciting a specific protective response in the guinea pig respiratory tract.
肺宿主防御。
DOI：
10.1097/00005382-199810000-00003
发表时间：
1998
期刊：
Journal of thoracic imaging.
影响因子：
--
作者：
Twigg3rd,HL
通讯作者：
Twigg3rd,HL