Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma.
Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma.
复制标题
父亲的脂质代谢营养程序通过精子和精浆传播。
DOI：
10.1007/s11306-022-01869-9
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发表时间：
2022-02-10
期刊：
影响因子：
--
通讯作者：
Koulman A
中科院分区：
文献类型：
--
作者：
Furse S;Watkins AJ;Williams HEL;Snowden SG;Chiarugi D;Koulman A
父亲饮食通过营养规划影响后代的脂质代谢至少两代。但我们不知道它是如何传播给后代的。我们检验了这样一个假设，即父亲饮食引起的脂质代谢变化是通过精子而不是精浆传播的。我们应用了一种更新的、专门构建的计算网络分析工具，以在已知的父系营养规划小鼠模型上系统地控制脂质代谢（脂质流量分析v2.3）。分析表明，编程效应的两种可能途径，精子（基因）和精浆（对子宫环境的影响），都对后代的脂质代谢有明显的影响。此外，在后代的编程效果表明，脂质分布的变化比脂质生物合成的改变更重要。这些结果显示了子宫环境和基因如何影响后代的脂质代谢，增强了我们对父母饮食和后代代谢之间联系的理解。在线版本包含补充材料，可通过10.1007/s11306-022-01869-9获得。
The paternal diet affects lipid metabolism in offspring for at least two generations through nutritional programming. However, we do not know how this is propagated to the offspring. We tested the hypothesis that the changes in lipid metabolism that are driven by paternal diet are propagated through spermatozoa and not seminal plasma. We applied an updated, purpose-built computational network analysis tool to characterise control of lipid metabolism systemically (Lipid Traffic Analysis v2.3) on a known mouse model of paternal nutritional programming. The analysis showed that the two possible routes for programming effects, the sperm (genes) and seminal plasma (influence on the uterine environment), both have a distinct effect on the offspring’s lipid metabolism. Further, the programming effects in offspring suggest that changes in lipid distribution are more important than alterations in lipid biosynthesis. These results show how the uterine environment and genes both affect lipid metabolism in offspring, enhancing our understanding of the link between parental diet and metabolism in offspring. The online version contains supplementary material available at 10.1007/s11306-022-01869-9.
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影响因子：
64.8
作者：
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通讯作者：
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5.6
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