Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation.
Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation.
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DOI：
10.1002/bit.26074
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发表时间：
2017-03
影响因子：
3.8
通讯作者：
Sakiyama-Elbert SE
中科院分区：
文献类型：
--
作者：
Iyer NR;Wilems TS;Sakiyama-Elbert SE
脊髓损伤（SCI）的复杂病理学涉及一系列次生事件和抑制性屏障的形成，阻碍了损伤部位的再生，并通常导致运动功能不可逆转的丧失。SCI后内源性细胞的再生能力有限，这使得人们专注于开发既能提供神经保护又能提供神经再生益处的细胞疗法。干细胞已经成为一种候选细胞来源，因为它们能够自我更新和分化成多种专门的细胞类型。虽然伦理和安全问题在过去阻碍了干细胞的使用，但分离和分化方法的进步在很大程度上缓解了这些问题。干细胞生物学、遗传学和发育神经生物学的融合工作为特定脊髓细胞类型的定向分化提供了信息。移植后，这些干细胞衍生的群体可以取代丢失的细胞，提供营养支持，使存活的轴突重新髓鞘化，并形成有助于功能恢复的中继电路。随着基于干细胞的治疗进入临床试验，进一步完善干细胞分化和移植方法，包括涉及生物材料支架和药物递送的组合策略至关重要。
The complex pathology of spinal cord injury (SCI), involving a cascade of secondary events and the formation of inhibitory barriers, hampers regeneration across the lesion site and often results in irreversible loss of motor function. The limited regenerative capacity of endogenous cells after SCI has led to a focus on the development of cell therapies that can confer both neuroprotective and neuroregenerative benefits. Stem cells have emerged as a candidate cell source because of their ability to self-renew and differentiate into a multitude of specialized cell types. While ethical and safety concerns impeded the use of stem cells in the past, advances in isolation and differentiation methods have largely mitigated these issues. A confluence of work in stem cell biology, genetics, and developmental neurobiology has informed the directed differentiation of specific spinal cell types. After transplantation, these stem cell-derived populations can replace lost cells, provide trophic support, remyelinate surviving axons, and form relay circuits that contribute to functional recovery. Further refining stem cell differentiation and transplantation methods, including combinatorial strategies that involve biomaterial scaffolds and drug delivery, is critical as stem cell-based treatments enter clinical trials.
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影响因子：
25
作者：
Blanchard, Joel W.;Eade, Kevin T.;Szucs, Attila;Lo Sardo, Valentina;Tsunemoto, Rachel K.;Williams, Daniel;Sanna, Pietro Paolo;Baldwin, Kristin K.
通讯作者：
Baldwin, Kristin K.
影响因子：
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作者：
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通讯作者：
Barres, Ben A.
影响因子：
14
作者：
Ashton, Randolph S.;Banerjee, Akhilesh;Kane, Ravi S.
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影响因子：
14.8
作者：
Brewer, Gregory J.;Torricelli, John R.
通讯作者：
Torricelli, John R.
影响因子：
5.3
作者：
Coumans, JV;Lin, TTS;Bregman, BS
通讯作者：
Bregman, BS