Clinical importance of IL-22 cascade in IBD.
Clinical importance of IL-22 cascade in IBD.
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DOI：
10.1007/s00535-017-1401-7
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发表时间：
2018-04
影响因子：
6.3
通讯作者：
Mizoguchi E
中科院分区：
文献类型：
--
作者：
Mizoguchi A;Yano A;Himuro H;Ezaki Y;Sadanaga T;Mizoguchi E
IL-22是一种相对较新的细胞因子，其特征在于几种独特的生物学特性。在肠道中，IL-22的作用主要限于非淋巴细胞，如上皮细胞。有趣的是，IL-22的表达模式和主要细胞来源在大肠和小肠之间有明显差异。IL-22具有组成型激活STAT 3的能力，以通过刺激抗菌肽和粘蛋白的表达来促进上皮细胞再生和增强粘膜屏障完整性。值得注意的是，IL-22被表征为双面细胞因子，其在肠道炎症中不仅可以发挥保护作用，而且可以发挥有害作用，这取决于细胞因子环境，例如IL-23、T-bet和IL-22结合蛋白的表达水平。最重要的是，IL-22与炎症性肠病的临床相关性已得到充分强调。代表IBD的当前治疗目标的粘膜愈合可以由IL-22诱导。事实上，可以通过Ahr激活IL-22通路的靛蓝在临床试验中显示出对溃疡性结肠炎的强治疗作用。尽管IL-22具有有益作用，但IL-22通路的持续激活会增加结肠炎相关癌症的风险，特别是在IBD病史较长的患者中。这篇综述文章讨论了IL-22如何调节结肠炎，如何确定IL-22的有益作用与有害作用，以及为什么IL-22是IBD治疗的一个有希望的靶点。
IL-22 is a relatively new cytokine that is characterized by several unique biological properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such as epithelial cells. Interestingly, the expression pattern and major cellular source of IL-22 have distinct difference between large and small intestines. IL-22 possesses an ability to constitutively activate STAT3 for promoting epithelial cell regeneration and reinforcing mucosal barrier integrity through stimulating the expression of anti-bacterial peptide and mucins. Of note, IL-22 is characterized as a two-faced cytokine that can play not only protective but also deleterious roles in the intestinal inflammation depending on the cytokine environment such as the expression levels of IL-23, T-bet, and IL-22 binding protein. Most importantly, clinical relevance of IL-22 to inflammatory bowel disease has been well highlighted. Mucosal healing, which represents the current therapeutic goal for IBD, can be induced by IL-22. Indeed, indigo naturalis, which can activate IL-22 pathway through Ahr, has been shown in a clinical trial to exhibit a strong therapeutic effect on ulcerative colitis. Despite the beneficial effect of IL-22, continuous activation of the IL-22 pathway increases the risk of colitis-associated cancer, particularly in patients with an extended history of IBD. This review article discusses how IL-22 regulates colitis, how beneficial versus deleterious effects of IL-22 is determined, and why IL-22 represents a promising target for IBD therapy.
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影响因子：
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作者：
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作者：
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通讯作者：
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