Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species.
Melanization in response to wounding is ancestral in arthropods and conserved in albino cave species.
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DOI：
10.1038/s41598-017-17471-2
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发表时间：
2017-12-07
影响因子：
4.6
通讯作者：
Fong DW
中科院分区：
文献类型：
--
作者：
Bilandžija H;Laslo M;Porter ML;Fong DW
许多适应了无光地下栖息地的物种已经失去了所有的身体色素。然而，黑化是节肢动物伤口愈合的重要组成部分。我们切除了各种洞穴适应和地表生活的节肢动物的附肢。在大多数测试物种中，在损伤部位形成黑色凝块，甚至包括白化病洞穴适应物种。血块的深色是由于黑色素沉积。伤口黑化的速度是不相关的差异，在代谢率之间的表面和洞穴种群的片足类动物。螯肢鲎polyphemus，所有的等足类甲壳动物测试，和洞穴虾Troglocaris anophthalmus没有黑化伤口。T.无眼龙是一种与地下栖息地适应有关的无眼龙，但在等足类动物中，它似乎是一种与地下栖息地定居无关的共形龙。我们得出结论，伤口黑化i）是先天免疫的一个重要组成部分，因为它存在于所有主要的节肢动物谱系，ii）保留在大多数白化病洞穴物种，和iii）已失去了几次在节肢动物进化过程中，表明黑化不是节肢动物伤口愈合的一个不可或缺的组成部分。
Many species adapted to aphotic subterranean habitats have lost all body pigmentation. Yet, melanization is an important component of wound healing in arthropods. We amputated appendages in a variety of cave-adapted and surface-dwelling arthropods. A dark clot formed at the site of injury in most species tested, including even albino cave-adapted species. The dark coloration of the clots was due to melanin deposition. The speed of wound melanization was uncorrelated with a difference in metabolic rate between surface and cave populations of an amphipod. The chelicerate Limulus polyphemus, all isopod crustaceans tested, and the cave shrimp Troglocaris anophthalmus did not melanize wounds. The loss of wound melanization in T. anophthalmus was an apomorphy associated with adaptation to subterranean habitats, but in isopods it appeared to be a symplesiomorphy unrelated to colonization of subterranean habitats. We conclude that wound melanization i) is an important part of innate immunity because it was present in all major arthropod lineages, ii) is retained in most albino cave species, and iii) has been lost several times during arthropod evolution, indicating melanization is not an indispensable component of wound healing in arthropods.
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影响因子：
2.9
作者：
Bilandžija H;Cetković H;Jeffery WR
通讯作者：
Jeffery WR
影响因子：
3.7
作者：
Chevalier F;Herbinière-Gaboreau J;Bertaux J;Raimond M;Morel F;Bouchon D;Grève P;Braquart-Varnier C
通讯作者：
Braquart-Varnier C
DOI：
10.1073/pnas.0504982102
发表时间：
2005-08-09
影响因子：
11.1
作者：
Arakane, Y;Muthukrishnan, S;Kramer, KJ
通讯作者：
Kramer, KJ
影响因子：
3.8
作者：
Dittmer, NT;Suderman, RJ;Kanost, MR
通讯作者：
Kanost, MR
影响因子：
5.3
作者：
Bidla, Gawa;Hauling, Thomas;Theopold, Ulrich
通讯作者：
Theopold, Ulrich