Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR).
Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR).
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造血细胞移植后怀孕：国际血液和骨髓移植研究中心（CIBMTR）晚期效应工作委员会的报告。
DOI：
10.1016/j.bbmt.2010.07.009
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发表时间：
2011-02
影响因子：
4.3
通讯作者：
Majhail, Navneet S.
中科院分区：
文献类型：
--
作者：
Loren, Alison W.;Chow, Eric;Jacobsohn, David A.;Gilleece, Maria;Halter, Joerg;Joshi, Sarita;Wang, Zhiwei;Sobocinski, Kathleen A.;Gupta, Vikas;Hale, Gregory A.;Marks, David I.;Stadtmauer, Edward A.;Apperley, Jane;Cahn, Jean-Yves;Schouten, Harry C.;Lazarus, Hillard M.;Savani, Bipin N.;McCarthy, Philip L.;Jakubowski, Ann A.;Kamani, Naynesh R.;Hayes-Lattin, Brandon;Maziarz, Richard T.;Warwick, Anne B.;Sorror, Mohamed L.;Bolwel, Brian J.;Socie, Gerard;Wingard, John R.;Rizzo, J. Douglas;Majhail, Navneet S.
关键词：
Preservation of fertility after hematopoietic-cell transplantation (HCT) can have a significant influence on the quality of life of transplant survivors. We describe 178 pregnancies in HCT recipients that were reported to the CIBMTR between 2002 and 2007. There were 83 pregnancies in female HCT recipients and 95 pregnancies in female partners of male HCT recipients. Indications for transplantation included hematologic and other malignancies (N=99) and non-malignant disorders (N=79, of which 75 patients had severe aplastic anemia). The cohort included recipients of autologous HCT (20 women, 13 men), myeloablative allogeneic HCT (12 women, 50 men) and non-myeloablative allogeneic HCT (2 women, 2 men). Age at HCT was <20 years for 50% of women and 19% of men. Conditioning regimens included total body irradiation (TBI) in 16% of women and 19% of men; doses were myeloablative in 10% of women and in 16% of men. Live births were reported in 86% of pregnancies in partners of male transplant patients and 85% of pregnancies in female transplant patients, with most pregnancies occurring 5-10 years after HCT. We conclude that some HCT recipients can retain fertility, including patients who have received TBI and/or myeloablative conditioning. Young patients undergoing HCT should be counseled both before and after HCT about potential loss of fertility, methods for preserving fertility and planning for future pregnancy. Fertility and outcomes of pregnancy after HCT need prospective evaluation in large transplant cohorts.
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影响因子：
45.3
作者：
SANDERS, JE;BUCKNER, CD;THOMAS, ED
通讯作者：
THOMAS, ED
影响因子：
4.3
作者：
Rodriguez, Roberto;Nademanee, Auayporn;Forman, Stephen J.
通讯作者：
Forman, Stephen J.
DOI：
10.1002/mpo.2950110514
发表时间：
1983-01-01
期刊：
MEDICAL AND PEDIATRIC ONCOLOGY
影响因子：
--
作者：
SKLAR, CA;KIM, TH;RAMSAY, NKC
通讯作者：
RAMSAY, NKC
影响因子：
4.8
作者：
Carter, A.;Robison, L. L.;Bhatia, S.
通讯作者：
Bhatia, S.
影响因子：
20.3
作者：
Sanders, JE;Hawley, J;Appelbaum, FR
通讯作者：
Appelbaum, FR