Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults.
Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults.
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老年人的慢性压力、社会支持和自然杀伤细胞对细胞因子反应的持续改变。
DOI：
10.1037//0278-6133.13.4.291
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Glaser,R
中科院分区：
文献类型：
--
作者：
Esterling,BA;Kiecolt-Glaser,JK;Bodnar,JC;Glaser,R
To address the long-term physiological consequences of chronic stressors, 14 continuing or current family caregivers of Alzheimer's disease (AD) patients, 17 former AD caregivers, and 31 control subjects were compared. Continuing and former caregivers did not differ on depressive symptomatology or perceived stress; both groups were significantly more depressed and stressed than controls. Furthermore, continuing and former caregivers did not differ in the response of NK cells in vitro to recombinant interferon-γ and recombinant interleukin-2, and both groups had a significantly poorer response to these cytokines than controls. The physiological and psychological consequences of chronic stressors may persist well beyond the cessation of the actual stressor.
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