The making of a node: a co-production of neurons and glia.

The making of a node: a co-production of neurons and glia.
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DOI:
10.1016/j.conb.2013.06.003
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发表时间:
2013-12
影响因子:
5.7
通讯作者:
Peles E
Peles E
中科院分区:
医学2区
文献类型:
--
作者:
Eshed-Eisenbach Y;Peles E

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朗飞结是响应神经胶质信号而形成的特殊轴突域。最近的研究进展表明,中枢神经系统和三七总皂苷节点都是通过几种重叠的分子机制形成的。然而,这些机制的确切性质以及它们之间存在的层次结构在 CNS 与 PNS 节点中存在很大不同。也就是说,PNS 的雪旺细胞直接接触结节轴突,分泌蛋白质,将轴突成分聚集在生长的髓磷脂段的边缘。相反,不与髓鞘神经胶质细胞接触的中枢神经系统节点的形成与轴突初始段的组装惊人地相似,并且很大程度上取决于轴突扩散屏障。
Nodes of Ranvier are specialized axonal domains formed in response to a glial signal. Recent research advances have revealed that both CNS and PNS nodes form by several overlapping molecular mechanisms. However, the precise nature of these mechanisms and the hierarchy existing between them is considerably different in CNS vs. PNS nodes. Namely, the Schwann cells of the PNS, which directly contact the nodal axolemma, secrete proteins that cluster axonodal components at the edges of the growing myelin segment. In contrast, the formation of CNS nodes, which are not contacted by the myelinating glia, is surprisingly similar to the assembly of the axon initial segment and depends largely on axonal diffusion barriers.
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